Juvenile Idiopathic Arthritis (JIA)

Also known as: Idiopathic Juvenile Arthritis / Arthritis Juvenile Idiopathic / Arthritis, Juvenile Idiopathic / Juvenile Arthritis / Arthritis, Juvenile / Juvenile Idiopathic Arthritis / Juvenile arthritis, unspecified / Juvenile idiopathic arthritis (disorder)

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidA salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.
DB01401Choline magnesium trisalicylateCholine magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB00586DiclofenacAn NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB00749EtodolacAn NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain.
DB01050IbuprofenAn NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
DB01097LeflunomideA pyrimidine synthesis inhibitor indicated to treat rheumatoid arthritis.
DB00939Meclofenamic acidAn NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis.
DB00788NaproxenAn NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
DB09029SecukinumabAn immunomodulating agent and interleukin antagonist used to manage plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, along with other joint inflammatory disorders.
DB00620TriamcinoloneA glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidATP-dependent translocase ABCB1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acidEndoplasmic reticulum chaperone BiPtarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidOrganic anion transporter 3transporter
DB00945Acetylsalicylic acidSialidase-1target
DB00945Acetylsalicylic acid3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 2target
DB00091CyclosporineGuided entry of tail-anchored proteins factor CAMLGtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineATP-dependent translocase ABCB1transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineHepatic sodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineATP-binding cassette sub-family C member 10transporter
DB00091CyclosporineATP-binding cassette sub-family C member 2transporter
DB00091CyclosporineBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB00091CyclosporineProtein phosphatase 3 catalytic subunit alphatarget
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacAlbumincarrier
DB00586DiclofenacATP-binding cassette sub-family C member 4transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacOrganic anion transporter 3transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB00586DiclofenacUDP-glucuronosyltransferase 1A3enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1A9enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 2B4enzyme
DB00586DiclofenacPolyunsaturated fatty acid 5-lipoxygenaseenzyme
DB00586DiclofenacSodium channel protein type 4 subunit alphatransporter
DB00586DiclofenacAcid-sensing ion channel 1transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3transporter
DB00586DiclofenacPhospholipase A2, membrane associatedenzyme
DB00586DiclofenacATP-dependent translocase ABCB1transporter
DB00749EtodolacProstaglandin G/H synthase 1target
DB00749EtodolacProstaglandin G/H synthase 2target
DB00749EtodolacCytochrome P450 2C9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1A9enzyme
DB00749EtodolacRetinoic acid receptor RXR-alphatarget
DB00749EtodolacAlbumincarrier
DB00749EtodolacSolute carrier family 22 member 6transporter
DB00749EtodolacUDP-glucuronosyltransferase 1A3enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1A10enzyme
DB00749EtodolacUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenAlbumincarrier
DB01050IbuprofenATP-binding cassette sub-family C member 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenOrganic anion transporter 3transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenATP-dependent translocase ABCB1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1A3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1A9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenCytochrome P450 3A4enzyme
DB01050IbuprofenC-X-C chemokine receptor type 1target
DB01050IbuprofenC-X-C chemokine receptor type 2target
DB01050IbuprofenInterleukin-8target
DB01097LeflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01097LeflunomideCytochrome P450 1A2enzyme
DB01097LeflunomideCytochrome P450 2C9enzyme
DB01097LeflunomideAryl hydrocarbon receptortarget
DB01097LeflunomideProtein-tyrosine kinase 2-betatarget
DB01097LeflunomideBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB01097LeflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB00939Meclofenamic acidProstaglandin G/H synthase 1target
DB00939Meclofenamic acidProstaglandin G/H synthase 2target
DB00939Meclofenamic acidPolyunsaturated fatty acid 5-lipoxygenasetarget
DB00939Meclofenamic acidSolute carrier family 22 member 6transporter
DB00939Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
DB00939Meclofenamic acidThyroxine-binding globulincarrier
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenAlbumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenATP-dependent translocase ABCB1transporter
DB00788NaproxenUDP-glucuronosyltransferase 1A3enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-6enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1A7enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1A8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1A9enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1A10enzyme
DB00788NaproxenOrganic anion transporter 3transporter
DB00788NaproxenPancreatic triacylglycerol lipasetarget
DB09029SecukinumabInterleukin-17Atarget
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DB00620TriamcinoloneCytochrome P450 3A5enzyme
DB00620TriamcinoloneCytochrome P450 3A7enzyme
DB00620TriamcinoloneAlbumincarrier
DrugDrug NamePhaseStatusCount
DB00736Esomeprazole1Completed1
DB00005Etanercept1Not Yet Recruiting1
DB14845Filgotinib1Recruiting1
DB00788Naproxen1Completed1
DB06273Tocilizumab1Completed4
DB08895Tofacitinib1Completed1
DB15091Upadacitinib1Active Not Recruiting1
DB05679Ustekinumab1Completed1
DB00111Daclizumab2Completed1
DB14724Emapalumab2Completed1
DB17088Famtozinameran2Completed1
DB17090Imelasomeran2Completed1
DB15857Janssen COVID-19 Vaccine2Completed1
DB00563Methotrexate2Completed1
DB15654Moderna COVID-19 Vaccine2Completed1
DB00688Mycophenolate mofetil2Completed1
DB01024Mycophenolic acid2Completed1
DB06372Rilonacept2Completed1
DB11767Sarilumab2Completed1
DB11767Sarilumab2Recruiting1
DB15696Tozinameran2Completed1
DB00051Adalimumab2 / 3Completed1
DB11105Benzalkonium2 / 3Completed1
DB08895Tofacitinib2 / 3Active Not Recruiting1
DB01281Abatacept3Active Not Recruiting1
DB01281Abatacept3Completed2
DB00051Adalimumab3Completed3
DB11817Baricitinib3Completed1
DB11817Baricitinib3Recruiting1
DB00442Entecavir3Terminated1
DB00005Etanercept3Completed2
DB06674Golimumab3Active Not Recruiting1
DB06674Golimumab3Terminated1
DB11834Guselkumab3Recruiting1
DB00065Infliximab3Completed1
DB00281Lidocaine3Completed1
DB00563Methotrexate3Active Not Recruiting1
DB00563Methotrexate3Completed3
DB00563Methotrexate3Terminated1
DB00052Somatotropin3Completed1
DB00795Sulfasalazine3Completed1
DB06273Tocilizumab3Completed6
DB06273Tocilizumab3Recruiting1
DB06273Tocilizumab3Terminated1
DB08895Tofacitinib3Completed2
DB15091Upadacitinib3Recruiting1
DB05679Ustekinumab3Recruiting1
DB00633Dexmedetomidine4Completed1
DB00736Esomeprazole4Completed1
DB00005Etanercept4Completed1
DB00005Etanercept4Unknown Status1
DB00927Famotidine4Completed1
DB11621Human varicella-zoster immune globulin4Recruiting1
DB01050Ibuprofen4Completed1
DB01097Leflunomide4Unknown Status1
DB00563Methotrexate4Completed1
DB00788Naproxen4Completed1
DB00860Prednisolone4Completed1
DB00635Prednisone4Completed1
DB06273Tocilizumab4Completed2
DB00620Triamcinolone4Active Not Recruiting1
DB13924Varicella zoster vaccine (recombinant)4Recruiting1
DB00051AdalimumabNot AvailableCompleted1
DB00091CyclosporineNot AvailableCompleted1
DB00005EtanerceptNot AvailableCompleted1
DB12645GivinostatNot AvailableTerminated1
DB00650LeucovorinNot AvailableActive Not Recruiting1
DB00563MethotrexateNot AvailableActive Not Recruiting1
DB00563MethotrexateNot AvailableCompleted1
DB00563MethotrexateNot AvailableUnknown Status1
DB00904OndansetronNot AvailableActive Not Recruiting1
DB06273TocilizumabNot AvailableNo Longer Available1
DB10805Yellow fever vaccineNot AvailableCompleted1