Otitis Media (OM)

Also known as: Otitis Media / Ear infection / Otitis media NOS / Middle ear infection / Unspecified otitis media / Middle ear inflammation / Catarrh of middle ear

DrugDrug NameDrug Description
DB01435AntipyrineAn antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine.
DB04339CarbocisteineA expectorant mucolytic used in the relief of respiratory of COPD and other conditions associated with increased mucus viscosity.
DB01416CefpodoximeA third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.
DB00567CephalexinA first generation cephalosporin used to treat certain susceptible bacterial infections.
DB00537CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
DB01211ClarithromycinA macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
DB00766Clavulanic acidA beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.
DB00687FludrocortisoneA mineralocorticoid used to treat adrenocortical insufficiency and salt-losing adrenogenital syndrome.
DB13456MidecamycinA macrolide antibiotic used to treat a variety of infections caused by susceptible bacteria.
DB06711NaphazolineA sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion.
DB13261SitafloxacinA fluoroquinolone antibiotic indicated in the treatment of susceptible bacterial infections.
DrugDrug NameTargetType
DB01435AntipyrineCytochrome P450 2C8enzyme
DB01435AntipyrineCytochrome P450 2C9enzyme
DB01435AntipyrineCytochrome P450 1A2enzyme
DB01435AntipyrineCytochrome P450 2C19enzyme
DB01435AntipyrineCytochrome P450 3A4enzyme
DB01435AntipyrineSolute carrier family 22 member 6transporter
DB01435AntipyrineCytochrome P450 2A6enzyme
DB01435AntipyrineCytochrome P450 2B6enzyme
DB01435AntipyrineCytochrome P450 2C18enzyme
DB01435AntipyrineCytochrome P450 2D6enzyme
DB01435AntipyrineCytochrome P450 2E1enzyme
DB01435AntipyrineProstaglandin G/H synthase 2target
DB01435AntipyrineProstaglandin G/H synthase 1target
DB04339CarbocisteineCysteine dioxygenase type 1enzyme
DB04339CarbocisteinePhenylalanine-4-hydroxylaseenzyme
DB04339CarbocisteinePI-PLC X domain-containing protein 3target
DB04339CarbocisteineLactosylceramide alpha-2,3-sialyltransferaseenzyme
DB04339CarbocisteineLactosylceramide alpha-2,3-sialyltransferasetarget
DB01416CefpodoximePeptidoglycan synthase FtsItarget
DB00567CephalexinSerum albumincarrier
DB00567CephalexinSolute carrier family 22 member 5transporter
DB00567CephalexinSolute carrier family 15 member 1transporter
DB00567CephalexinSolute carrier family 15 member 2transporter
DB00567CephalexinSolute carrier family 22 member 6transporter
DB00567CephalexinSolute carrier family 22 member 8transporter
DB00567CephalexinMultidrug and toxin extrusion protein 1transporter
DB00567CephalexinPenicillin-binding protein 3target
DB00567CephalexinPenicillin-binding protein 2atarget
DB00567CephalexinPenicillin-binding protein 1btarget
DB00567CephalexinPenicillin-binding protein 1Atarget
DB00567CephalexinPenicillin-binding protein 2Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 2-alphatarget
DB00537CiprofloxacinCytochrome P450 1A2enzyme
DB00537CiprofloxacinCytochrome P450 3A4enzyme
DB00537CiprofloxacinCytochrome P450 3A5enzyme
DB00537CiprofloxacinCytochrome P450 3A7enzyme
DB00537CiprofloxacinP-glycoprotein 1transporter
DB00537CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Atarget
DB00537CiprofloxacinDNA topoisomerase 4 subunit Btarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug resistance protein MdtKtarget
DB00537CiprofloxacinGyrase Atarget
DB00537CiprofloxacinDNA gyrase subunit Atarget
DB00537CiprofloxacinMultidrug and toxin extrusion protein 1transporter
DB00537CiprofloxacinMultidrug and toxin extrusion protein 2transporter
DB00537CiprofloxacinSerum albumincarrier
DB01211Clarithromycin50S ribosomal protein L10target
DB01211ClarithromycinCytochrome P450 3A4enzyme
DB01211ClarithromycinCytochrome P450 3A5enzyme
DB01211ClarithromycinP-glycoprotein 1transporter
DB01211ClarithromycinSolute carrier family 22 member 7transporter
DB01211ClarithromycinPotassium voltage-gated channel subfamily H member 2target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1target
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3target
DB01211ClarithromycinBile salt export pumptransporter
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B1transporter
DB01211ClarithromycinSolute carrier organic anion transporter family member 1B3transporter
DB00766Clavulanic acidBacterial beta-lactamase enzymesenzyme
DB00766Clavulanic acidBacterial beta-lactamase enzymestarget
DB00766Clavulanic acidSodium/glucose cotransporter 1transporter
DB00687FludrocortisoneMineralocorticoid receptortarget
DB00687FludrocortisoneGlucocorticoid receptortarget
DB00687FludrocortisoneCytochrome P450 3A4enzyme
DB00687FludrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
DB00687FludrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB00687FludrocortisoneSerum albumincarrier
DB00687FludrocortisoneCorticosteroid-binding globulincarrier
DB13456MidecamycinCytochrome P450 3A4enzyme
DB06711NaphazolineAlpha-1A adrenergic receptortarget
DB06711NaphazolineAlpha-2A adrenergic receptortarget
DB13261SitafloxacinCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB11129Carbamide peroxide1Unknown Status1
DB09047Finafloxacin1Withdrawn1
DB11774Pazufloxacin1Unknown Status1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB00319Piperacillin1 / 2Active Not Recruiting1
DB01606Tazobactam1 / 2Active Not Recruiting1
DB01086Benzocaine2Completed1
DB05659Faropenem medoxomil2Completed1
DB09512Simethicone2Completed1
DB01060Amoxicillin3Completed1
DB00207Azithromycin3Completed1
DB00537Ciprofloxacin3Completed1
DB01211Clarithromycin3Completed1
DB00766Clavulanic acid3Completed1
DB01137Levofloxacin3Completed2
DB01165Ofloxacin3Completed1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen3Unknown Status1
DB10332Streptococcus pneumoniae type 14 capsular polysaccharide antigen3Unknown Status1
DB10335Streptococcus pneumoniae type 18c capsular polysaccharide antigen3Unknown Status1
DB10337Streptococcus pneumoniae type 19a capsular polysaccharide antigen3Unknown Status1
DB10336Streptococcus pneumoniae type 19f capsular polysaccharide antigen3Unknown Status1
DB10340Streptococcus pneumoniae type 23f capsular polysaccharide antigen3Unknown Status1
DB10321Streptococcus pneumoniae type 3 capsular polysaccharide antigen3Unknown Status1
DB10322Streptococcus pneumoniae type 4 capsular polysaccharide antigen3Unknown Status1
DB10323Streptococcus pneumoniae type 5 capsular polysaccharide antigen3Unknown Status1
DB10296Streptococcus pneumoniae type 6A capsular polysaccharide diphtheria CRM197 protein conjugate antigen3Unknown Status1
DB10324Streptococcus pneumoniae type 6b capsular polysaccharide antigen3Unknown Status1
DB10325Streptococcus pneumoniae type 7f capsular polysaccharide antigen3Unknown Status1
DB10328Streptococcus pneumoniae type 9v capsular polysaccharide antigen3Unknown Status1
DB00976Telithromycin3Completed1
DB00976Telithromycin3Terminated1
DB06151Acetylcysteine4Withdrawn1
DB01060Amoxicillin4Completed1
DB01060Amoxicillin4Not Yet Recruiting1
DB00537Ciprofloxacin4Withdrawn1
DB00766Clavulanic acid4Not Yet Recruiting1
DB01234Dexamethasone4Withdrawn1
DB00003Dornase alfa4Completed1
DB00813Fentanyl4Completed1
DB00813Fentanyl4Unknown Status1
DB00465Ketorolac4Unknown Status1
DB00471Montelukast4Completed1
DB00295Morphine4Completed1
DB01165Ofloxacin4Recruiting1
DB10319Streptococcus pneumoniae type 1 capsular polysaccharide antigen4Completed2
DB10332Streptococcus pneumoniae type 14 capsular polysaccharide antigen4Completed2
DB10335Streptococcus pneumoniae type 18c capsular polysaccharide antigen4Completed2
DB10336Streptococcus pneumoniae type 19f capsular polysaccharide antigen4Completed2
DB10340Streptococcus pneumoniae type 23f capsular polysaccharide antigen4Completed2
DB10322Streptococcus pneumoniae type 4 capsular polysaccharide antigen4Completed2
DB10323Streptococcus pneumoniae type 5 capsular polysaccharide antigen4Completed2
DB10324Streptococcus pneumoniae type 6b capsular polysaccharide antigen4Completed2
DB10325Streptococcus pneumoniae type 7f capsular polysaccharide antigen4Completed2
DB10328Streptococcus pneumoniae type 9v capsular polysaccharide antigen4Completed2
DB11129Carbamide peroxideNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableUnknown Status1