Cystic Fibrosis, Homozygous for the F508del CFTR Mutation

Drug	Drug Name	Drug Description
DB11712	Tezacaftor	A medication used to treat homozygous or heterozygous F508del mutation cystic fibrosis.

Drug	Drug Name	Target	Type
DB11712	Tezacaftor	Cytochrome P450 3A4	enzyme
DB11712	Tezacaftor	Cytochrome P450 3A5	enzyme
DB11712	Tezacaftor	Cystic fibrosis transmembrane conductance regulator	target
DB11712	Tezacaftor	P-glycoprotein 1	transporter
DB11712	Tezacaftor	ATP-binding cassette sub-family G member 2	transporter
DB11712	Tezacaftor	Solute carrier family 22 member 2	transporter
DB11712	Tezacaftor	Solute carrier family 22 member 6	transporter
DB11712	Tezacaftor	Solute carrier family 22 member 8	transporter
DB11712	Tezacaftor	Solute carrier organic anion transporter family member 1B1	transporter
DB11712	Tezacaftor	Cytochrome P450 1A2	enzyme
DB11712	Tezacaftor	Cytochrome P450 2B6	enzyme
DB11712	Tezacaftor	Cytochrome P450 2C8	enzyme
DB11712	Tezacaftor	Cytochrome P450 2C9	enzyme
DB11712	Tezacaftor	Cytochrome P450 2C19	enzyme
DB11712	Tezacaftor	Cytochrome P450 2D6	enzyme
DB11712	Tezacaftor	Solute carrier organic anion transporter family member 1B3	transporter

Drug	Drug Name	Phase	Status	Count
DB08820	Ivacaftor	3	Completed	2
DB09280	Lumacaftor	3	Completed	2