Endogenous Cushing's Syndrome

Also known as: Endogenous Cushing Syndrome

DrugDrug NameDrug Description
DB01026KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
DB05667LevoketoconazoleOne of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome.
DrugDrug NameTargetType
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleP-glycoprotein 1transporter
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB01026KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
DB01026KetoconazoleCytochrome P450 4F12enzyme
DB01026KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
DB01026KetoconazoleSerum albumincarrier
DB01026KetoconazoleSex hormone-binding globulincarrier
DB01026KetoconazoleCytochrome P450 19A1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
DB05667LevoketoconazoleCytochrome P450 11B1, mitochondrialtarget
DB05667LevoketoconazoleLanosterol 14-alpha demethylasetarget
DB05667LevoketoconazoleCytochrome P450 3A4enzyme
DB05667LevoketoconazoleCytochrome P450 3A5enzyme
DB05667LevoketoconazoleSteroid 21-hydroxylaseenzyme
DB05667LevoketoconazoleP-glycoprotein 1transporter
DB05667LevoketoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB05667LevoketoconazoleCytochrome P450 11B2, mitochondrialtarget
DB05667LevoketoconazoleCholesterol side-chain cleavage enzyme, mitochondrialtarget
DB05667LevoketoconazoleSolute carrier family 22 member 2transporter
DB05667LevoketoconazoleMultidrug and toxin extrusion protein 1transporter
DB05667LevoketoconazoleCytochrome P450 2B6enzyme
DB05667LevoketoconazoleCytochrome P450 2C8enzyme
DB05667LevoketoconazoleCytochrome P450 1A2enzyme
DB05667LevoketoconazoleCytochrome P450 7A1enzyme
DB05667LevoketoconazoleCytochrome P450 19A1enzyme
DrugDrug NamePhaseStatusCount
DB05667Levoketoconazole3Completed2
DB11837OsilodrostatNot AvailableRecruiting1