Acute Heart Failure (AHF)

Also known as: Heart Failure Acute / Acute Heart Failure / Cardiac failure acute / Acute Cardiac Failure / Acute cardiac insufficiency / Acute heart failure (disorder)

Drug	Drug Name	Drug Description
DB00922	Levosimendan	A calcium sensitizer indicated to treat acutely decompensated severe chronic heart failure.
DB13401	Metildigoxin	A digitalis glycoside indicated in the treatment of acute and chronic heart failure.
DB00325	Nitroprusside	A direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.

Drug	Drug Name	Target	Type
DB00922	Levosimendan	Troponin C, slow skeletal and cardiac muscles	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 11	target
DB00922	Levosimendan	ATP-sensitive inward rectifier potassium channel 8	target
DB00922	Levosimendan	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	target
DB00325	Nitroprusside	Atrial natriuretic peptide receptor 1	target
DB00325	Nitroprusside	Cytochrome P450 1A1	enzyme

Drug	Drug Name	Phase	Status	Count
DB00695	Furosemide	1	Completed	1
DB09055	Acipimox	2	Terminated	1
DB14983	Cimlanod	2	Completed	1
DB16126	Cinaciguat	2	Terminated	2
DB01914	D-glucose	2	Completed	1
DB00988	Dopamine	2	Completed	1
DB09038	Empagliflozin	2	Completed	1
DB09038	Empagliflozin	2	Terminated	1
DB16730	Enibarcimab	2	Recruiting	1
DB00695	Furosemide	2	Terminated	1
DB09083	Ivabradine	2	Unknown Status	1
DB04398	Lactic acid	2	Completed	1
DB00922	Levosimendan	2	Terminated	1
DB06655	Liraglutide	2	Completed	1
DB04899	Nesiritide	2	Completed	1
DB14049	Nitrate	2	Terminated	1
DB14498	Potassium acetate	2	Completed	1
DB05794	Serelaxin	2	Completed	2
DB05794	Serelaxin	2	Terminated	1
DB00421	Spironolactone	2	Withdrawn	1
DB00887	Bumetanide	2 / 3	Completed	1
DB00695	Furosemide	2 / 3	Completed	1
DB00727	Nitroglycerin	2 / 3	Completed	1
DB09140	Oxygen	2 / 3	Not Yet Recruiting	1
DB00635	Prednisone	2 / 3	Not Yet Recruiting	1
DB00214	Torasemide	2 / 3	Completed	1
DB00819	Acetazolamide	3	Unknown Status	1
DB04920	Clevidipine	3	Withdrawn	1
DB00390	Digoxin	3	Recruiting	1
DB00841	Dobutamine	3	Completed	1
DB09038	Empagliflozin	3	Recruiting	2
DB00695	Furosemide	3	Recruiting	1
DB01275	Hydralazine	3	Unknown Status	1
DB00999	Hydrochlorothiazide	3	Recruiting	1
DB00883	Isosorbide dinitrate	3	Unknown Status	1
DB00922	Levosimendan	3	Completed	1
DB00524	Metolazone	3	Unknown Status	1
DB05794	Serelaxin	3	Completed	1
DB05794	Serelaxin	3	Terminated	2
DB09422	Soybean oil	3	Withdrawn	1
DB00421	Spironolactone	3	Recruiting	1
DB06558	Tezosentan	3	Completed	2
DB06212	Tolvaptan	3	Unknown Status	1
DB00819	Acetazolamide	4	Recruiting	1
DB00887	Bumetanide	4	Recruiting	1
DB00796	Candesartan cilexetil	4	Completed	1
DB09015	Canrenoic acid	4	Recruiting	1
DB00880	Chlorothiazide	4	Terminated	1
DB00310	Chlorthalidone	4	Recruiting	1
DB06292	Dapagliflozin	4	Recruiting	1
DB00841	Dobutamine	4	Withdrawn	1
DB00988	Dopamine	4	Unknown Status	1
DB09038	Empagliflozin	4	Recruiting	1
DB00584	Enalapril	4	Completed	1
DB00695	Furosemide	4	Completed	1
DB00695	Furosemide	4	Not Yet Recruiting	1
DB00695	Furosemide	4	Recruiting	1
DB00695	Furosemide	4	Terminated	1
DB00695	Furosemide	4	Unknown Status	1
DB00695	Furosemide	4	Withdrawn	1
DB00999	Hydrochlorothiazide	4	Recruiting	1
DB00159	Icosapent	4	Unknown Status	1
DB08887	Icosapent ethyl	4	Unknown Status	1
DB00883	Isosorbide dinitrate	4	Not Yet Recruiting	1
DB01020	Isosorbide mononitrate	4	Completed	1
DB00922	Levosimendan	4	Enrolling by Invitation	1
DB00524	Metolazone	4	Terminated	2
DB04899	Nesiritide	4	Terminated	1
DB00727	Nitroglycerin	4	Completed	1
DB00325	Nitroprusside	4	Withdrawn	1
DB14500	Potassium	4	Recruiting	1
DB00178	Ramipril	4	Completed	1
DB06228	Rivaroxaban	4	Unknown Status	1
DB09292	Sacubitril	4	Completed	1
DB00421	Spironolactone	4	Unknown Status	1
DB00177	Valsartan	4	Completed	1
DB00682	Warfarin	4	Unknown Status	1
DB00695	Furosemide	Not Available	Unknown Status	1
DB12212	Landiolol	Not Available	Recruiting	1
DB00325	Nitroprusside	Not Available	Completed	1
DB06212	Tolvaptan	Not Available	Recruiting	1