Dyslipidemia (Fredrickson Type Ⅱa)

Also known as: Type IIa hyperlipidaemia / Type IIa Hypercholesterolemia / Primary Hypercholesterolaemia / Primary Hypercholesterolemia / Familial Hypercholesterolaemia / Familial Hypercholesterolemia / Hypercholesterolemia, Familial / Type IIa hyperlipoproteinemia / Hyperlipoproteinemia Type IIa / Fredrickson Type IIa hyperlipoproteinemia / Type IIa hyperlipoproteinaemia / Pure hypercholesterolemia / Fredrickson Type IIa hyperlipoproteinaemia / Fredrickson Type IIa hyperlipidemia / Fredrickson Type IIa hyperlipidaemia / Fredrickson Type IIa lipidemia / Fredrickson Type IIa lipidaemia / Type IIa hyperlipidemia / Type II lipidemia / Type II lipidaemia / Hyperlipoproteinemia Type II / Type II hyperlipoproteinaemia / Type II hyperlipoproteinemia / Fredrickson Type II hyperlipidaemia / Fredrickson Type II lipidemia / Fredrickson Type II hyperlipidemia / Type II hyperlipidaemia / Fredrickson Type II lipidaemia / Type II hyperlipidemia

DrugDrug NameDrug Description
DB00381AmlodipineA calcium channel blocker used to treat hypertension and angina.
DB01076AtorvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB01393BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
DB01432CholestyramineA bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
DB00375ColestipolA bile acid sequestrant used as an adjunct to diet and exercise to reduce LDL-C cholesterol levels in patients with primary hypercholesterolemia.
DB01039FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
DB13873Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
DB01095FluvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB14901InclisiranA PCSK9-targeted short interfering RNA that lowers plasma LDL-cholesterol levels.
DB01098RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DrugDrug NameTargetType
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineP-glycoprotein 1transporter
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00381AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00381AmlodipineVoltage-dependent N-type calcium channeltarget
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinP-glycoprotein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01076AtorvastatinSerum albumincarrier
DB01076AtorvastatinHistone deacetylase 2target
DB01076AtorvastatinNuclear receptor subfamily 1 group I member 3target
DB01393BezafibratePeroxisome proliferator-activated receptor alphatarget
DB01393BezafibrateSolute carrier organic anion transporter family member 1B1transporter
DB01393BezafibratePeroxisome proliferator-activated receptor deltatarget
DB01393BezafibratePeroxisome proliferator-activated receptor gammatarget
DB01393BezafibrateCytochrome P450 1A1enzyme
DB01393BezafibrateCytochrome P450 2C8enzyme
DB01393BezafibrateCytochrome P450 3A4enzyme
DB01393BezafibrateNuclear receptor subfamily 1 group I member 2target
DB01393BezafibrateRetinoic acid receptor RXR-alphatarget
DB01393BezafibrateRetinoic acid receptor RXR-betatarget
DB01393BezafibrateRetinoic acid receptor RXR-gammatarget
DB01432CholestyramineBile acidstarget
DB00375ColestipolBile acidstarget
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMatrix metalloproteinase-25target
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-9enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01039FenofibrateSerum albumincarrier
DB01039FenofibrateCytochrome P450 2C19enzyme
DB01039FenofibrateCytochrome P450 2A6enzyme
DB01039FenofibrateLiver carboxylesterase 1enzyme
DB01039FenofibrateCarbonyl reductase [NADPH] 1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C2enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C3enzyme
DB01039FenofibrateAldose reductaseenzyme
DB13873Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
DB13873Fenofibric acidMatrix metalloproteinase-25target
DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
DB13873Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
DB13873Fenofibric acidNuclear receptor subfamily 1 group I member 2target
DB01095Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01095FluvastatinCytochrome P450 2C9enzyme
DB01095FluvastatinCytochrome P450 3A4enzyme
DB01095FluvastatinCytochrome P450 2C8enzyme
DB01095FluvastatinCytochrome P450 2D6enzyme
DB01095FluvastatinCytochrome P450 2C19enzyme
DB01095FluvastatinCytochrome P450 1A1enzyme
DB01095FluvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01095FluvastatinSolute carrier family 15 member 1transporter
DB01095FluvastatinCytochrome P450 3A5enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01095FluvastatinCanalicular multispecific organic anion transporter 1transporter
DB01095FluvastatinCytochrome P450 2B6enzyme
DB01095FluvastatinHistone deacetylase 2target
DB14901InclisiranProprotein convertase subtilisin/kexin type 9target
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DB01098RosuvastatinSodium/bile acid cotransportertransporter
DB01098RosuvastatinIntegrin alpha-Ltarget
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid1Completed1
DB01076Atorvastatin1Completed1
DB00758Clopidogrel1Completed1
DB01039Fenofibrate1Completed1
DB11629Laropiprant1Completed1
DB11629Laropiprant1Terminated1
DB00627Niacin1Completed1
DB00627Niacin1Terminated1
DB09153Sodium chloride1Active Not Recruiting1
DB05035Eprotirome2Completed1
DB09303Evolocumab2Active Not Recruiting1
DB09303Evolocumab2Completed1
DB04852Implitapide2Terminated2
DB14901Inclisiran2Active Not Recruiting1
DB14901Inclisiran2Completed1
DB05528Mipomersen2Completed1
DB12433SCH-9002712Completed1
DB06630Anacetrapib3Completed1
DB01076Atorvastatin3Completed7
DB01076Atorvastatin3Unknown Status1
DB01432Cholestyramine3Completed1
DB00736Esomeprazole3Completed1
DB09303Evolocumab3Active Not Recruiting1
DB09303Evolocumab3Completed2
DB09303Evolocumab3Terminated1
DB00973Ezetimibe3Active Not Recruiting1
DB00973Ezetimibe3Completed5
DB00973Ezetimibe3Recruiting2
DB00973Ezetimibe3Terminated1
DB11629Laropiprant3Completed3
DB11629Laropiprant3Terminated4
DB08827Lomitapide3Completed1
DB00627Niacin3Completed3
DB00627Niacin3Terminated4
DB09567Olive oil3Completed1
DB11133Omega-3 fatty acids3Completed1
DB09539Omega-3-acid ethyl esters3Completed1
DB08860Pitavastatin3Active Not Recruiting1
DB08860Pitavastatin3Completed1
DB08860Pitavastatin3Recruiting1
DB01098Rosuvastatin3Completed5
DB01098Rosuvastatin3Recruiting1
DB00641Simvastatin3Completed4
DB00641Simvastatin3Terminated2
DB00966Telmisartan3Recruiting1
DB06281Torcetrapib3Completed3
DB01076Atorvastatin4Completed1
DB00930Colesevelam4Completed1
DB09303Evolocumab4Terminated1
DB00973Ezetimibe4Completed1
DB09539Omega-3-acid ethyl esters4Unknown Status1
DB01098Rosuvastatin4Completed1
DB01098Rosuvastatin4Withdrawn1
DB09302AlirocumabNot AvailableNot Yet Recruiting1
DB00381AmlodipineNot AvailableCompleted1
DB01076AtorvastatinNot AvailableCompleted1
DB00169CholecalciferolNot AvailableUnknown Status1
DB09303EvolocumabNot AvailableNot Yet Recruiting1
DB09303EvolocumabNot AvailableRecruiting1
DB00973EzetimibeNot AvailableCompleted3
DB01098RosuvastatinNot AvailableCompleted1
DB11094Vitamin DNot AvailableUnknown Status1