Mixed Dyslipidemias

Also known as: Mixed Hyperlipidaemia / Mixed Dyslipidemia / Mixed Hyperlipidemia / Mixed hypercholesterolemia / Broad- or floating-betalipoproteinemia / Type V hyperlipidaemia / Type V hyperlipidemia / Type V lipidaemia / Type V lipidemia / Hyperlipoproteinemia Type V / Type V hyperlipoproteinemia / Fredrickson Type V lipidemia / Fredrickson Type V lipidaemia / Type V hyperlipoproteinaemia

DrugDrug NameDrug Description
DB00381AmlodipineA calcium channel blocker used to treat hypertension and angina.
DB01076AtorvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB01039FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
DB13873Fenofibric acidA fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia.
DB01095FluvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB14901InclisiranA PCSK9-targeted short interfering RNA that lowers plasma LDL-cholesterol levels.
DB00627NiacinA B vitamin used to treat hypertriglyceridemia and pellagra.
DB08860PitavastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB00175PravastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and to reduce the risk of cardiovascular events, including myocardial infarction and stroke.
DB01098RosuvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DrugDrug NameTargetType
DB00381AmlodipineCarbonic anhydrase 1target
DB00381AmlodipineCytochrome P450 3A4enzyme
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00381AmlodipineCytochrome P450 1A1enzyme
DB00381AmlodipineCytochrome P450 2B6enzyme
DB00381AmlodipineVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00381AmlodipineVoltage-dependent L-type calcium channel subunit beta-1target
DB00381AmlodipineVoltage-dependent calcium channel subunit alpha-2/delta-3target
DB00381AmlodipineCytochrome P450 3A5enzyme
DB00381AmlodipineP-glycoprotein 1transporter
DB00381AmlodipineCytochrome P450 2C8enzyme
DB00381AmlodipineCytochrome P450 2D6enzyme
DB00381AmlodipineSphingomyelin phosphodiesterasetarget
DB00381AmlodipineVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00381AmlodipineVoltage-dependent N-type calcium channeltarget
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinP-glycoprotein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01076AtorvastatinSerum albumincarrier
DB01076AtorvastatinHistone deacetylase 2target
DB01076AtorvastatinNuclear receptor subfamily 1 group I member 3target
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMatrix metalloproteinase-25target
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-9enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01039FenofibrateSerum albumincarrier
DB01039FenofibrateCytochrome P450 2C19enzyme
DB01039FenofibrateCytochrome P450 2A6enzyme
DB01039FenofibrateLiver carboxylesterase 1enzyme
DB01039FenofibrateCarbonyl reductase [NADPH] 1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C2enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C3enzyme
DB01039FenofibrateAldose reductaseenzyme
DB13873Fenofibric acidPeroxisome proliferator-activated receptor alphatarget
DB13873Fenofibric acidMatrix metalloproteinase-25target
DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammatarget
DB13873Fenofibric acidPeroxisome proliferator-activated receptor deltatarget
DB13873Fenofibric acidNuclear receptor subfamily 1 group I member 2target
DB01095Fluvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01095FluvastatinCytochrome P450 2C9enzyme
DB01095FluvastatinCytochrome P450 3A4enzyme
DB01095FluvastatinCytochrome P450 2C8enzyme
DB01095FluvastatinCytochrome P450 2D6enzyme
DB01095FluvastatinCytochrome P450 2C19enzyme
DB01095FluvastatinCytochrome P450 1A1enzyme
DB01095FluvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01095FluvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01095FluvastatinSolute carrier family 15 member 1transporter
DB01095FluvastatinCytochrome P450 3A5enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01095FluvastatinUDP-glucuronosyltransferase 2B7enzyme
DB01095FluvastatinCanalicular multispecific organic anion transporter 1transporter
DB01095FluvastatinCytochrome P450 2B6enzyme
DB01095FluvastatinHistone deacetylase 2target
DB14901InclisiranProprotein convertase subtilisin/kexin type 9target
DB00627NiacinHydroxycarboxylic acid receptor 2target
DB00627NiacinNicotinamide N-methyltransferasetarget
DB00627NiacinNicotinate-nucleotide pyrophosphorylase [carboxylating]target
DB00627NiacinHydroxycarboxylic acid receptor 3target
DB00627NiacinSolute carrier family 22 member 5transporter
DB00627NiacinSolute carrier organic anion transporter family member 2B1transporter
DB00627NiacinMonocarboxylate transporter 1transporter
DB00627NiacinCytochrome P450 2D6enzyme
DB00627NiacinSodium-coupled monocarboxylate transporter 1transporter
DB00627NiacinMonocarboxylate transporter 4transporter
DB00627NiacinThyroxine-binding globulincarrier
DB00627NiacinCytochrome P450 3A4enzyme
DB00627NiacinCytochrome P450 2E1enzyme
DB08860PitavastatinSolute carrier organic anion transporter family member 1B1transporter
DB08860PitavastatinSolute carrier organic anion transporter family member 1B3transporter
DB08860PitavastatinUDP-glucuronosyltransferase 2B7enzyme
DB08860PitavastatinUDP-glucuronosyltransferase 1-3enzyme
DB08860PitavastatinCytochrome P450 2C9enzyme
DB08860PitavastatinCytochrome P450 2C8enzyme
DB08860Pitavastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB08860PitavastatinSolute carrier organic anion transporter family member 2B1transporter
DB08860PitavastatinSodium/bile acid cotransportertransporter
DB08860PitavastatinATP-binding cassette sub-family G member 2transporter
DB08860PitavastatinP-glycoprotein 1transporter
DB08860PitavastatinCanalicular multispecific organic anion transporter 1transporter
DB08860PitavastatinSerum albumincarrier
DB08860PitavastatinAlpha-1-acid glycoprotein 1carrier
DB08860PitavastatinBile salt export pumptransporter
DB08860PitavastatinIntegrin alpha-Ltarget
DB00175Pravastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00175PravastatinSolute carrier organic anion transporter family member 2B1transporter
DB00175PravastatinP-glycoprotein 1transporter
DB00175PravastatinSolute carrier organic anion transporter family member 1A2transporter
DB00175PravastatinSolute carrier family 22 member 6transporter
DB00175PravastatinSolute carrier family 22 member 8transporter
DB00175PravastatinCanalicular multispecific organic anion transporter 1transporter
DB00175PravastatinSolute carrier family 22 member 11transporter
DB00175PravastatinATP-binding cassette sub-family G member 2transporter
DB00175PravastatinSolute carrier family 22 member 7transporter
DB00175PravastatinSolute carrier organic anion transporter family member 1B1transporter
DB00175PravastatinMonocarboxylate transporter 1transporter
DB00175PravastatinBile salt export pumptransporter
DB00175PravastatinSolute carrier organic anion transporter family member 1B3transporter
DB00175PravastatinHistone deacetylase 2target
DB01098Rosuvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01098RosuvastatinCytochrome P450 2C9enzyme
DB01098RosuvastatinMultidrug resistance-associated protein 4transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01098RosuvastatinCystine/glutamate transportertransporter
DB01098RosuvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01098RosuvastatinBile salt export pumptransporter
DB01098RosuvastatinATP-binding cassette sub-family G member 2transporter
DB01098RosuvastatinSerum albumincarrier
DB01098RosuvastatinCanalicular multispecific organic anion transporter 1transporter
DB01098RosuvastatinSolute carrier family 22 member 8transporter
DB01098RosuvastatinSodium/bile acid cotransportertransporter
DB01098RosuvastatinIntegrin alpha-Ltarget
DrugDrug NamePhaseStatusCount
DB09303Evolocumab1Completed1
DB04115Berberine2Unknown Status1
DB01393Bezafibrate2Unknown Status1
DB01377Magnesium oxide2Unknown Status1
DB01076Atorvastatin3Completed6
DB09303Evolocumab3Completed3
DB09303Evolocumab3Terminated1
DB00973Ezetimibe3Completed1
DB00973Ezetimibe3Recruiting1
DB01039Fenofibrate3Completed1
DB13873Fenofibric acid3Completed6
DB01095Fluvastatin3Completed2
DB11629Laropiprant3Completed1
DB11629Laropiprant3Terminated2
DB00627Niacin3Completed2
DB00627Niacin3Terminated2
DB08860Pitavastatin3Recruiting1
DB01098Rosuvastatin3Completed4
DB00641Simvastatin3Completed6
DB00641Simvastatin3Terminated1
DB09539Omega-3-acid ethyl esters4Unknown Status1
DB08860Pitavastatin4Completed1
DB00175Pravastatin4Completed1
DB00641Simvastatin4Unknown Status1
DB11936Bempedoic acidNot AvailableRecruiting1
DB00973EzetimibeNot AvailableRecruiting1
DB01039FenofibrateNot AvailableCompleted1
DB11629LaropiprantNot AvailableTerminated1
DB00627NiacinNot AvailableTerminated1
DB09539Omega-3-acid ethyl estersNot AvailableCompleted1
DB00641SimvastatinNot AvailableCompleted2