PIK3CA-Related Overgrowth Spectrum (PROS)

Also known as: PIK3CA-related Overgrowth Spectrum / PIK3CA Related Overgrowth Spectrum / Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha related overgrowth syndrome (disorder)

Drug	Drug Name	Drug Description
DB12015	Alpelisib	Alpelisib is indicated in combination with fulvestrant to treat postmenopausal women, and men, with advanced or metastatic breast cancer. This cancer must be hormone receptor (HR)-positive, human epidermal growth factor...

Drug	Drug Name	Target	Type
DB12015	Alpelisib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	target
DB12015	Alpelisib	Cytochrome P450 3A4	enzyme
DB12015	Alpelisib	Cytochrome P450 2C9	enzyme
DB12015	Alpelisib	Cytochrome P450 2C8	enzyme
DB12015	Alpelisib	Cytochrome P450 2C19	enzyme
DB12015	Alpelisib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
DB12015	Alpelisib	ATP-dependent translocase ABCB1	transporter

Drug	Drug Name	Phase	Status	Count
DB12015	Alpelisib	Not Available	Available	1
DB14982	Miransertib	Not Available	No Longer Available	1
DB12015	Alpelisib	2	Active Not Recruiting	1
DB12015	Alpelisib	2	Not Yet Recruiting	1
DB12015	Alpelisib	2	Recruiting	1
DB07101	Mirdametinib	2	Not Yet Recruiting	1
DB14954	PIK3CA	2	Completed	1
DB00877	Sirolimus	2	Completed	1