Trigeminal Neuralgia (TN)

Also known as: Tic Douloureux / Trigeminal Neuralgia / Syndrome of paroxysmal facial pain / Neuralgia trigeminal / Tic doloreux

DrugDrug NameDrug Description
DB00083Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
DB00564CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DB01403MethotrimeprazineA phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
DB00165PyridoxineA vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
DrugDrug NameTargetType
DB00083Botulinum toxin type ASynaptosomal-associated protein 25target
DB00083Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
DB00083Botulinum toxin type ASerum albumincarrier
DB00564CarbamazepineVoltage-gated sodium channel alpha subunittarget
DB00564CarbamazepineCytochrome P450 2C8enzyme
DB00564CarbamazepineCytochrome P450 2B6enzyme
DB00564CarbamazepineCytochrome P450 3A4enzyme
DB00564CarbamazepineCytochrome P450 1A2enzyme
DB00564CarbamazepineCytochrome P450 2C19enzyme
DB00564CarbamazepineCytochrome P450 2C9enzyme
DB00564CarbamazepineP-glycoprotein 1transporter
DB00564CarbamazepineCytochrome P450 3A5enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
DB00564CarbamazepineRalA-binding protein 1transporter
DB00564CarbamazepineCanalicular multispecific organic anion transporter 1transporter
DB00564CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
DB00564CarbamazepineNuclear receptor subfamily 1 group I member 2target
DB00564CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DB01403MethotrimeprazineDopamine D3 receptortarget
DB01403MethotrimeprazineHistamine H1 receptortarget
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M1target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M2target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M3target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M4target
DB01403MethotrimeprazineMuscarinic acetylcholine receptor M5target
DB01403MethotrimeprazineAlpha-1A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-1D adrenergic receptortarget
DB01403MethotrimeprazineCytochrome P450 2D6enzyme
DB01403MethotrimeprazineDopamine D2 receptortarget
DB01403MethotrimeprazineDopamine D1 receptortarget
DB01403MethotrimeprazineDopamine D5 receptortarget
DB01403MethotrimeprazineDopamine D4 receptortarget
DB01403MethotrimeprazineAlpha-2A adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2B adrenergic receptortarget
DB01403MethotrimeprazineAlpha-2C adrenergic receptortarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Atarget
DB01403Methotrimeprazine5-hydroxytryptamine receptor 2Ctarget
DB01403MethotrimeprazineCytochrome P450 2E1enzyme
DB00165PyridoxinePyridoxal kinasetarget
DB00165PyridoxineCytochrome P450 1A1enzyme
DB00165PyridoxineSerum albumincarrier
DB00165PyridoxinePyridoxal kinaseenzyme
DB00165PyridoxinePyridoxal phosphate phosphataseenzyme
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymetransporter
DB00165PyridoxineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DrugDrug NamePhaseStatusCount
DB01234Dexamethasone1Withdrawn1
DB00465Ketorolac1Withdrawn1
DB11706Vixotrigine1Completed2
DB00083Botulinum toxin type A1 / 2Completed1
DB04077Glycerin1 / 2Terminated1
DB00083Botulinum toxin type A2Terminated1
DB09157Carbon dioxide2Completed1
DB00514Dextromethorphan2Completed1
DB14039Erenumab2Unknown Status1
DB01018Guanfacine2Active Not Recruiting1
DB00281Lidocaine2Active Not Recruiting1
DB12457Rimegepant2Terminated1
DB11706Vixotrigine2Completed1
DB11833Basimglurant2 / 3Recruiting1
DB00564Carbamazepine2 / 3Completed1
DB00555Lamotrigine2 / 3Completed1
DB01143Amifostine3Terminated1
DB00083Botulinum toxin type A3Unknown Status1
DB11706Vixotrigine3Withdrawn1
DB00564Carbamazepine4Recruiting1
DB14042Galcanezumab4Completed1
DB01221Ketamine4Unknown Status1
DB00281Lidocaine4Completed1
DB00904Ondansetron4Unknown Status1
DB00776Oxcarbazepine4Recruiting1
DB00776Oxcarbazepine4Withdrawn1
DB00708Sufentanil4Unknown Status1
DB00744Zileuton4Recruiting1
DB00564CarbamazepineNot AvailableCompleted1
DB01320FosphenytoinNot AvailableCompleted1
DB12098L-BaclofenNot AvailableCompleted1
DB00555LamotrigineNot AvailableCompleted1
DB00281LidocaineNot AvailableCompleted2
DB00776OxcarbazepineNot AvailableCompleted1