IDH1 Gene Mutation
Also known as: Isocitrate dehydrogenase gene mutation
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB14568 | Ivosidenib | An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB14568 | Ivosidenib | Isocitrate dehydrogenase [NADP] cytoplasmic | target |
| DB14568 | Ivosidenib | Cytochrome P450 3A4 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2B6 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2C9 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2C8 | enzyme |
| DB14568 | Ivosidenib | Solute carrier family 22 member 8 | transporter |
| DB14568 | Ivosidenib | P-glycoprotein 1 | transporter |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB14769 | Pamiparib | 1 | Recruiting | 1 |
| DB00853 | Temozolomide | 1 | Recruiting | 1 |
| DB01008 | Busulfan | 2 | Terminated | 1 |
| DB00531 | Cyclophosphamide | 2 | Terminated | 1 |
| DB01073 | Fludarabine | 2 | Terminated | 1 |
| DB14568 | Ivosidenib | 2 | Recruiting | 1 |
| DB00853 | Temozolomide | 2 | Active Not Recruiting | 1 |