Moderate to severe pain

Also known as: Moderate-severe Pain

DrugDrug NameDrug Description
DB00316AcetaminophenAn analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.
DB11979ElagolixA gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.
DB00327HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00423MethocarbamolA CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
DB00727NitroglycerinA nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively.
DB00656TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
DrugDrug NameTargetType
DB00316AcetaminophenProstaglandin G/H synthase 1target
DB00316AcetaminophenProstaglandin G/H synthase 2target
DB00316AcetaminophenCytochrome P450 1A2enzyme
DB00316AcetaminophenCytochrome P450 2E1enzyme
DB00316AcetaminophenP-glycoprotein 1transporter
DB00316AcetaminophenCytochrome P450 2D6enzyme
DB00316AcetaminophenCytochrome P450 2A6enzyme
DB00316AcetaminophenCytochrome P450 3A4enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-1enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-6enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 1-9enzyme
DB00316AcetaminophenUDP-glucuronosyltransferase 2B15enzyme
DB00316AcetaminophenSulfotransferase 1A1enzyme
DB00316AcetaminophenSulfotransferase 1A3/1A4enzyme
DB00316AcetaminophenArylamine N-acetyltransferase 2enzyme
DB00316AcetaminophenProstaglandin E synthase 3target
DB00316AcetaminophenTransient receptor potential cation channel subfamily V member 1target
DB00316AcetaminophenSerum albumincarrier
DB00316AcetaminophenFatty-acid amide hydrolase 1enzyme
DB00316AcetaminophenGlutathione S-transferase Penzyme
DB00316AcetaminophenGlutathione S-transferase Mu 1enzyme
DB11979ElagolixGonadotropin-releasing hormone receptortarget
DB11979ElagolixCytochrome P450 3A Subfamilyenzyme
DB11979ElagolixCytochrome P450 2D6enzyme
DB11979ElagolixCytochrome P450 2C8enzyme
DB11979ElagolixP-glycoprotein 1transporter
DB11979ElagolixSolute carrier organic anion transporter family member 1B1transporter
DB00327HydromorphoneMu-type opioid receptortarget
DB00327HydromorphoneDelta-type opioid receptortarget
DB00327HydromorphoneKappa-type opioid receptortarget
DB00327HydromorphoneCytochrome P450 2C9enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
DB00327HydromorphoneSerum albumincarrier
DB00423MethocarbamolCarbonic anhydrase 1target
DB00727NitroglycerinAtrial natriuretic peptide receptor 1target
DB00727NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneP-glycoprotein 1transporter
DB00656Trazodone5-hydroxytryptamine receptor 1Ctarget
DrugDrug NamePhaseStatusCount
DB00704Naltrexone4Terminated1
DB00497Oxycodone4Terminated1