Severe Alzheimer's Type Dementia

Also known as: Severe dementia of the Alzheimer's type / Severe Dementia Alzheimer's type

Drug	Drug Name	Drug Description
DB00843	Donepezil	An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia.
DB01043	Memantine	An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.

Drug	Drug Name	Target	Type
DB00843	Donepezil	Acetylcholinesterase	target
DB00843	Donepezil	5-hydroxytryptamine receptor 2A	target
DB00843	Donepezil	Cytochrome P450 3A4	enzyme
DB00843	Donepezil	Cytochrome P450 2D6	enzyme
DB00843	Donepezil	Cytochrome P450 2C9	enzyme
DB00843	Donepezil	Cholinesterase	target
DB00843	Donepezil	Nitric oxide synthase, brain	target
DB00843	Donepezil	Tumor necrosis factor-inducible gene 6 protein	target
DB00843	Donepezil	Interleukin-1 beta	target
DB00843	Donepezil	Nuclear factor NF-kappa-B	target
DB00843	Donepezil	ATP-binding cassette sub-family G member 2	transporter
DB00843	Donepezil	NMDA receptor	target
DB01043	Memantine	Cytochrome P450 2B6	enzyme
DB01043	Memantine	Solute carrier family 22 member 2	transporter
DB01043	Memantine	5-hydroxytryptamine receptor 3A	target
DB01043	Memantine	Neuronal acetylcholine receptor subunit alpha-7	target
DB01043	Memantine	Cytochrome P450 2A6	enzyme
DB01043	Memantine	Cytochrome P450 2C19	enzyme
DB01043	Memantine	Dopamine D2 receptor	target
DB01043	Memantine	Glutamate receptor ionotropic, NMDA 1	target
DB01043	Memantine	Sodium/hydrogen exchanger 1	transporter
DB01043	Memantine	Solute carrier family 22 member 4	transporter
DB01043	Memantine	Multidrug and toxin extrusion protein 1	transporter
DB01043	Memantine	Glutamate (NMDA) receptor	target
DB01043	Memantine	GABA(A) Receptor	target
DB01043	Memantine	Glycine receptors	target

Drug	Drug Name	Phase	Status	Count