Refractory Acute Myeloid Leukemia (AML)

Also known as: Acute Myeloid Leukaemia Refractory / Acute Myeloid Leukemia, Refractory / Acute, refractory Myeloid Leukemia / Acute Myeloid Leukemia Refractory / Refractory AML / Refractory Acute Myeloid Leukemia / Refractory Acute Myelogenous Leukemia (AML) / Refractory Acute Myelogenous Leukemia / Acute, refractory Myelogenous Leukemia / Refractory acute myeloid leukemia (disorder)

DrugDrug NameDrug Description
DB00631ClofarabineA purine nucleoside used to treat relapsed or refractory acute lymphoblastic leukemia in patients 1 to 21 years old.
DB13874EnasidenibAn isocitrate dehydrogenase-2 inhibitor used to treat relapsed or refractory acute myeloid leukemia with an isocitrate dehydrogenase-2 mutation.
DB00056Gemtuzumab ozogamicinA monoclonal anti-CD33 antibody used to treat CD33-positive acute myeloid leukemia.
DB14568IvosidenibAn isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation.
DB16267OlutasidenibAn isocitrate dehydrogenase-1 (IDH1) inhibitor indicated for the treatment of patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation as detected by an FDA-approved test.
DrugDrug NameTargetType
DB00631ClofarabineDNA polymerase alpha catalytic subunittarget
DB00631ClofarabineRibonucleoside-diphosphate reductase large subunittarget
DB00631ClofarabineDeoxycytidine kinaseenzyme
DB00631ClofarabineDNAtarget
DB00631ClofarabineATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibCytochrome P450 1A2enzyme
DB13874EnasidenibCytochrome P450 2B6enzyme
DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB13874EnasidenibCytochrome P450 2C8enzyme
DB13874EnasidenibCytochrome P450 2C9enzyme
DB13874EnasidenibCytochrome P450 2C19enzyme
DB13874EnasidenibCytochrome P450 2D6enzyme
DB13874EnasidenibCytochrome P450 3A4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-1enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-3enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-9enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B7enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B15enzyme
DB13874EnasidenibP-glycoprotein 1transporter
DB13874EnasidenibATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibSolute carrier family 22 member 6transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B1transporter
DB13874EnasidenibSolute carrier family 22 member 2transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B3transporter
DB13874EnasidenibSolute carrier family 22 member 8transporter
DB13874EnasidenibSerum albumincarrier
DB00056Gemtuzumab ozogamicinMyeloid cell surface antigen CD33target
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00056Gemtuzumab ozogamicinLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00056Gemtuzumab ozogamicinHigh affinity immunoglobulin gamma Fc receptor Itarget
DB14568IvosidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB14568IvosidenibCytochrome P450 3A4enzyme
DB14568IvosidenibCytochrome P450 2B6enzyme
DB14568IvosidenibCytochrome P450 2C9enzyme
DB14568IvosidenibCytochrome P450 2C8enzyme
DB14568IvosidenibSolute carrier family 22 member 8transporter
DB14568IvosidenibP-glycoprotein 1transporter
DB16267OlutasidenibIsocitrate dehydrogenase [NADP] cytoplasmictarget
DB16267OlutasidenibCytochrome P450 3A4enzyme
DB16267OlutasidenibCytochrome P450 2C8enzyme
DB16267OlutasidenibCytochrome P450 2C9enzyme
DB16267OlutasidenibCytochrome P450 1A2enzyme
DB16267OlutasidenibCytochrome P450 2C19enzyme
DB16267OlutasidenibP-glycoprotein 1transporter
DB16267OlutasidenibATP-binding cassette sub-family G member 2transporter
DB16267OlutasidenibSolute carrier organic anion transporter family member 1B1transporter
DB16267OlutasidenibSolute carrier organic anion transporter family member 1B3transporter
DB16267OlutasidenibSolute carrier family 22 member 8transporter
DB16267OlutasidenibSolute carrier family 22 member 2transporter
DB16267OlutasidenibMultidrug and toxin extrusion protein 1transporter
DB16267OlutasidenibMultidrug and toxin extrusion protein 2transporter
DB16267OlutasidenibCytochrome P450 2B6enzyme
DrugDrug NamePhaseStatusCount
DB15721Natural Killer Cell0Recruiting1
DB09037Pembrolizumab0Withdrawn1
DB160758-Chloroadenosine1Recruiting1
DB12001Abemaciclib1Terminated1
DB05812Abiraterone1Terminated1
DB11740Adavosertib1Terminated1
DB00640Adenosine1Recruiting1
DB08916Afatinib1Terminated1
DB00062Albumin human1Terminated1
DB09495Avobenzone1Terminated1
DB00928Azacitidine1Active Not Recruiting1
DB00928Azacitidine1Completed2
DB00928Azacitidine1Not Yet Recruiting1
DB00928Azacitidine1Recruiting1
DB05015Belinostat1Active Not Recruiting1
DB05015Belinostat1Terminated1
DB11105Benzalkonium1Recruiting1
DB00112Bevacizumab1Terminated1
DB01128Bicalutamide1Terminated1
DB17247Bisantrene1Withdrawn1
DB17234Bomedemstat1Recruiting1
DB00188Bortezomib1Terminated1
DB16741Bortezomib D-mannitol1Terminated1
DB15722CYNK-0011Recruiting1
DB06772Cabazitaxel1Terminated1
DB08875Cabozantinib1Completed1
DB08875Cabozantinib1Terminated1
DB01373Calcium1Not Yet Recruiting1
DB01101Capecitabine1Terminated1
DB00958Carboplatin1Terminated1
DB15694Cedazuridine1Recruiting1
DB15694Cedazuridine1Withdrawn1
DB00482Celecoxib1Terminated1
DB14707Cemiplimab1Recruiting1
DB00242Cladribine1Not Yet Recruiting1
DB00242Cladribine1Recruiting2
DB00242Cladribine1Terminated1
DB05239Cobimetinib1Recruiting1
DB05239Cobimetinib1Terminated1
DB12483Copanlisib1Terminated1
DB00531Cyclophosphamide1Active Not Recruiting3
DB00531Cyclophosphamide1Recruiting3
DB00091Cyclosporine1Recruiting1
DB00987Cytarabine1Active Not Recruiting2
DB00987Cytarabine1Completed6
DB00987Cytarabine1Not Yet Recruiting3
DB00987Cytarabine1Recruiting12
DB00987Cytarabine1Terminated3
DB00987Cytarabine1Withdrawn1
DB08912Dabrafenib1Terminated1
DB11963Dacomitinib1Terminated1
DB12941Darolutamide1Terminated1
DB01254Dasatinib1Terminated1
DB00694Daunorubicin1Recruiting3
DB00694Daunorubicin1Terminated1
DB01262Decitabine1Active Not Recruiting2
DB01262Decitabine1Completed2
DB01262Decitabine1Recruiting7
DB01262Decitabine1Withdrawn2
DB01234Dexamethasone1Recruiting1
DB00590Doxazosin1Recruiting1
DB00997Doxorubicin1Terminated1
DB11714Durvalumab1Terminated1
DB14598Edetate calcium disodium anhydrous1Recruiting1
DB00974Edetic acid1Recruiting1
DB13874Enasidenib1Recruiting1
DB13874Enasidenib1Terminated1
DB11986Entrectinib1Recruiting1
DB11986Entrectinib1Terminated1
DB08899Enzalutamide1Terminated1
DB00530Erlotinib1Terminated1
DB00898Ethanol1Not Yet Recruiting1
DB00773Etoposide1Completed2
DB00773Etoposide1Recruiting1
DB01590Everolimus1Terminated1
DB17383FN-15011Terminated1
DB11680Ficlatuzumab1Terminated1
DB00099Filgrastim1Completed1
DB00099Filgrastim1Not Yet Recruiting1
DB00099Filgrastim1Recruiting5
DB00099Filgrastim1Terminated1
DB15223Flotetuzumab1Active Not Recruiting1
DB01073Fludarabine1Active Not Recruiting4
DB01073Fludarabine1Completed3
DB01073Fludarabine1Not Yet Recruiting1
DB01073Fludarabine1Recruiting7
DB00544Fluorouracil1Terminated1
DB00056Gemtuzumab ozogamicin1Active Not Recruiting1
DB00056Gemtuzumab ozogamicin1Recruiting1
DB12141Gilteritinib1Not Yet Recruiting1
DB12141Gilteritinib1Recruiting1
DB14999Human interferon beta1Recruiting1
DB00741Hydrocortisone1Completed1
DB00741Hydrocortisone1Not Yet Recruiting2
DB00741Hydrocortisone1Recruiting1
DB14539Hydrocortisone acetate1Completed1
DB14545Hydrocortisone succinate1Not Yet Recruiting1
DB15126IMG-72891Recruiting1
DB01177Idarubicin1Recruiting1
DB09054Idelalisib1Terminated1
DB00619Imatinib1Terminated1
DB14909Imetelstat1Not Yet Recruiting1
DB06186Ipilimumab1Active Not Recruiting2
DB06186Ipilimumab1Recruiting1
DB06186Ipilimumab1Terminated1
DB02325Isopropyl alcohol1Recruiting1
DB14568Ivosidenib1Recruiting1
DB09570Ixazomib1Completed1
DB09078Lenvatinib1Terminated1
DB00650Leucovorin1Not Yet Recruiting1
DB00650Leucovorin1Recruiting1
DB00650Leucovorin1Terminated1
DB11596Levoleucovorin1Not Yet Recruiting1
DB12130Lorlatinib1Terminated1
DB00678Losartan1Terminated1
DB01033Mercaptopurine1Recruiting1
DB16620Methopterin1Completed1
DB16620Methopterin1Not Yet Recruiting1
DB00563Methotrexate1Completed1
DB00563Methotrexate1Not Yet Recruiting2
DB00563Methotrexate1Recruiting1
DB01204Mitoxantrone1Completed2
DB01204Mitoxantrone1Not Yet Recruiting1
DB01204Mitoxantrone1Recruiting3
DB01204Mitoxantrone1Terminated1
DB00688Mycophenolate mofetil1Recruiting1
DB01024Mycophenolic acid1Recruiting1
DB15721Natural Killer Cell1Completed1
DB15721Natural Killer Cell1Recruiting2
DB12340Navitoclax1Not Yet Recruiting1
DB12340Navitoclax1Recruiting1
DB15299Navtemadlin1Recruiting1
DB16252Nedisertib1Recruiting1
DB11828Neratinib1Terminated1
DB09079Nintedanib1Active Not Recruiting1
DB09035Nivolumab1Active Not Recruiting1
DB09035Nivolumab1Recruiting1
DB09035Nivolumab1Terminated1
DB16630OPB-1110771Completed1
DB16848ORY-10011Recruiting1
DB09496Octinoxate1Terminated1
DB09074Olaparib1Terminated1
DB00526Oxaliplatin1Terminated1
DB01229Paclitaxel1Terminated1
DB09073Palbociclib1Recruiting2
DB09073Palbociclib1Terminated1
DB06603Panobinostat1Terminated1
DB16281Pegcrisantaspase1Active Not Recruiting1
DB09037Pembrolizumab1Recruiting1
DB09037Pembrolizumab1Terminated1
DB06366Pertuzumab1Terminated1
DB11759Pevonedistat1Active Not Recruiting2
DB11759Pevonedistat1Completed1
DB08901Ponatinib1Terminated1
DB12008Prexasertib1Completed1
DB05213Quizartinib1Completed1
DB08896Regorafenib1Terminated1
DB18515Revumenib1Not Yet Recruiting2
DB08877Ruxolitinib1Active Not Recruiting1
DB08877Ruxolitinib1Terminated1
DB14797SEphB4-HSA1Terminated1
DB11942Selinexor1Active Not Recruiting1
DB11942Selinexor1Recruiting1
DB00877Sirolimus1Terminated1
DB11119Sodium iodide1Recruiting1
DB00398Sorafenib1Recruiting1
DB00398Sorafenib1Terminated1
DB00566Succimer1Recruiting1
DB01268Sunitinib1Terminated1
DB15013TAK-2431Not Yet Recruiting1
DB17414TK2161Withdrawn1
DB11760Talazoparib1Active Not Recruiting1
DB12887Tazemetostat1Recruiting1
DB08911Trametinib1Terminated1
DB05773Trastuzumab emtansine1Terminated1
DB00755Tretinoin1Terminated1
DB00135Tyrosine1Active Not Recruiting1
DB14829Uproleselan1Recruiting1
DB08881Vemurafenib1Terminated1
DB11581Venetoclax1Active Not Recruiting1
DB11581Venetoclax1Completed1
DB11581Venetoclax1Not Yet Recruiting2
DB11581Venetoclax1Recruiting10
DB11581Venetoclax1Terminated1
DB00541Vincristine1Terminated1
DB08828Vismodegib1Terminated1
DB02546Vorinostat1Completed1
DB02546Vorinostat1Recruiting1
DB02546Vorinostat1Terminated1
DB17171Ziftomenib1Recruiting1
DB160758-Chloroadenosine1 / 2Completed1
DB17115AB-89391 / 2Recruiting1
DB00640Adenosine1 / 2Completed1
DB00041Aldesleukin1 / 2Recruiting1
DB03496Alvocidib1 / 2Withdrawn1
DB11945Avelumab1 / 2Completed1
DB11945Avelumab1 / 2Terminated1
DB00928Azacitidine1 / 2Active Not Recruiting2
DB00928Azacitidine1 / 2Completed4
DB00928Azacitidine1 / 2Recruiting3
DB00928Azacitidine1 / 2Terminated1
DB01008Busulfan1 / 2Recruiting1
DB15694Cedazuridine1 / 2Recruiting2
DB15694Cedazuridine1 / 2Withdrawn1
DB00242Cladribine1 / 2Completed1
DB00242Cladribine1 / 2Recruiting1
DB09110Coenzyme M1 / 2Completed1
DB14681Cortisone1 / 2Completed1
DB00531Cyclophosphamide1 / 2Completed1
DB00531Cyclophosphamide1 / 2Recruiting2
DB00091Cyclosporine1 / 2Suspended1
DB00987Cytarabine1 / 2Completed3
DB00987Cytarabine1 / 2Recruiting4
DB00987Cytarabine1 / 2Terminated2
DB00987Cytarabine1 / 2Withdrawn1
DB00694Daunorubicin1 / 2Recruiting2
DB00694Daunorubicin1 / 2Withdrawn1
DB01262Decitabine1 / 2Completed2
DB01262Decitabine1 / 2Recruiting3
DB01262Decitabine1 / 2Withdrawn2
DB01234Dexamethasone1 / 2Completed1
DB14844Dordaviprone1 / 2Recruiting1
DB13874Enasidenib1 / 2Recruiting1
DB00898Ethanol1 / 2Withdrawn1
DB00099Filgrastim1 / 2Completed2
DB00099Filgrastim1 / 2Recruiting3
DB01073Fludarabine1 / 2Recruiting3
DB01073Fludarabine1 / 2Suspended1
DB01073Fludarabine1 / 2Withdrawn1
DB00056Gemtuzumab ozogamicin1 / 2Completed1
DB12141Gilteritinib1 / 2Active Not Recruiting2
DB12141Gilteritinib1 / 2Recruiting1
DB11978Glasdegib1 / 2Completed1
DB00741Hydrocortisone1 / 2Withdrawn1
DB14545Hydrocortisone succinate1 / 2Withdrawn1
DB17337IMGN6321 / 2Withdrawn1
DB01177Idarubicin1 / 2Recruiting2
DB14568Ivosidenib1 / 2Recruiting2
DB16208Ivuxolimab1 / 2Completed1
DB14770Lanraplenib1 / 2Active Not Recruiting1
DB00650Leucovorin1 / 2Completed1
DB16225Magrolimab1 / 2Active Not Recruiting1
DB16620Methopterin1 / 2Completed1
DB16620Methopterin1 / 2Withdrawn1
DB00563Methotrexate1 / 2Completed1
DB00563Methotrexate1 / 2Withdrawn1
DB00723Methoxamine1 / 2Completed1
DB00959Methylprednisolone1 / 2Completed1
DB01204Mitoxantrone1 / 2Completed1
DB00688Mycophenolate mofetil1 / 2Recruiting2
DB00688Mycophenolate mofetil1 / 2Suspended1
DB15721Natural Killer Cell1 / 2Recruiting1
DB16267Olutasidenib1 / 2Withdrawn1
DB04865Omacetaxine mepesuccinate1 / 2Recruiting1
DB00019Pegfilgrastim1 / 2Recruiting1
DB12920Pinometostat1 / 2Completed1
DB01263Posaconazole1 / 2Completed1
DB00860Prednisolone1 / 2Withdrawn1
DB00635Prednisone1 / 2Completed1
DB00635Prednisone1 / 2Withdrawn1
DB12874Quizartinib1 / 2Completed1
DB12874Quizartinib1 / 2Recruiting3
DB00073Rituximab1 / 2Completed1
DB08877Ruxolitinib1 / 2Completed1
DB00398Sorafenib1 / 2Recruiting1
DB00864Tacrolimus1 / 2Recruiting2
DB11581Venetoclax1 / 2Active Not Recruiting3
DB11581Venetoclax1 / 2Completed2
DB11581Venetoclax1 / 2Recruiting7
DB11581Venetoclax1 / 2Terminated1
DB11581Venetoclax1 / 2Withdrawn1
DB00541Vincristine1 / 2Completed1
DB00582Voriconazole1 / 2Completed1
DB019551,4-Butanediol2Completed1
DB00437Allopurinol2Terminated1
DB13906Aloe vera leaf2Withdrawn1
DB00126Ascorbic acid2Withdrawn1
DB17226Aspacytarabine2Active Not Recruiting1
DB15233Avapritinib2Recruiting1
DB00928Azacitidine2Completed3
DB00928Azacitidine2Not Yet Recruiting1
DB00928Azacitidine2Recruiting3
DB00928Azacitidine2Terminated1
DB00928Azacitidine2Withdrawn1
DB01008Busulfan2Completed1
DB01008Busulfan2Terminated1
DB01008Busulfan2Withdrawn1
DB00958Carboplatin2Active Not Recruiting1
DB15694Cedazuridine2Recruiting2
DB00242Cladribine2Completed1
DB00242Cladribine2Recruiting1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed1
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn2
DB00091Cyclosporine2Completed1
DB00091Cyclosporine2Withdrawn1
DB00987Cytarabine2Completed1
DB00987Cytarabine2Not Yet Recruiting1
DB00987Cytarabine2Recruiting5
DB00987Cytarabine2Withdrawn1
DB09331Daratumumab2Terminated1
DB01254Dasatinib2Terminated1
DB00694Daunorubicin2Completed1
DB00694Daunorubicin2Recruiting3
DB01262Decitabine2Active Not Recruiting2
DB01262Decitabine2Completed1
DB01262Decitabine2Not Yet Recruiting1
DB01262Decitabine2Recruiting3
DB12109Devimistat2Not Yet Recruiting1
DB00590Doxazosin2Recruiting2
DB13874Enasidenib2Recruiting2
DB13874Enasidenib2Withdrawn1
DB00099Filgrastim2Completed1
DB00099Filgrastim2Recruiting1
DB00099Filgrastim2Withdrawn1
DB01073Fludarabine2Active Not Recruiting1
DB01073Fludarabine2Completed2
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Withdrawn3
DB00056Gemtuzumab ozogamicin2Recruiting1
DB12141Gilteritinib2Recruiting2
DB09462Glycerin2Withdrawn1
DB14865Human interleukin-22Terminated1
DB14865Human interleukin-22Withdrawn2
DB01177Idarubicin2Recruiting2
DB09054Idelalisib2Terminated1
DB06186Ipilimumab2Completed1
DB02325Isopropyl alcohol2Recruiting2
DB14568Ivosidenib2Recruiting1
DB12504JNJ-403465272Terminated1
DB01202Levetiracetam2Terminated1
DB11754Lirilumab2Terminated1
DB00888Mechlorethamine2Completed1
DB01042Melphalan2Completed1
DB00331Metformin2Not Yet Recruiting1
DB16620Methopterin2Active Not Recruiting1
DB16620Methopterin2Withdrawn1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Withdrawn1
DB06595Midostaurin2Recruiting1
DB01204Mitoxantrone2Completed1
DB00688Mycophenolate mofetil2Active Not Recruiting1
DB00688Mycophenolate mofetil2Completed2
DB15721Natural Killer Cell2Withdrawn1
DB02701Nicotinamide2Withdrawn1
DB09035Nivolumab2Completed1
DB09074Olaparib2Active Not Recruiting1
DB11697Pacritinib2Terminated1
DB11759Pevonedistat2Withdrawn1
DB08901Ponatinib2Active Not Recruiting1
DB08901Ponatinib2Terminated1
DB08877Ruxolitinib2Terminated1
DB01399Salsalate2Completed1
DB00877Sirolimus2Completed1
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Completed1
DB00864Tacrolimus2Withdrawn1
DB17459Therapeutic allogeneic lymphocytes2Completed1
DB04572Thiotepa2Active Not Recruiting1
DB01030Topotecan2Active Not Recruiting1
DB08911Trametinib2Completed1
DB03754Tromethamine2Active Not Recruiting1
DB07232Veliparib2Active Not Recruiting1
DB11581Venetoclax2Active Not Recruiting2
DB11581Venetoclax2Completed2
DB11581Venetoclax2Not Yet Recruiting1
DB11581Venetoclax2Recruiting4
DB00162Vitamin A2Withdrawn1