Transplanted Organ Rejection

Also known as: Transplant rejections / Graft Rejection / Transplant Rejection / Rejection, Transplant / Organ Transplant Rejection / Transplanted organ rejection (disorder) / Graft rejection (finding) / Complication of transplanted organ (disorder)

Drug	Drug Name	Drug Description
DB00688	Mycophenolate mofetil	An inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
DB00860	Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB15566	Prednisolone acetate	A glucocorticoid used to treat a wide variety of endocrine, inflammatory, and immune conditions as well as for palliation of neoplastic conditions.
DB00877	Sirolimus	An mTOR inhibitor immunosuppressant used to prevent organ transplant rejections, treat lymphangioleiomyomatosis, and treat adults with perivascular epithelioid cell tumors.

Drug	Drug Name	Target	Type
DB00688	Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 2	target
DB00688	Mycophenolate mofetil	Inosine-5'-monophosphate dehydrogenase 1	target
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-1	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-7	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-6	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-9	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 2B7	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-8	enzyme
DB00688	Mycophenolate mofetil	UDP-glucuronosyltransferase 1-10	enzyme
DB00688	Mycophenolate mofetil	Liver carboxylesterase 1	enzyme
DB00688	Mycophenolate mofetil	Cytochrome P450 3A4	enzyme
DB00688	Mycophenolate mofetil	Cytochrome P450 3A5	enzyme
DB00688	Mycophenolate mofetil	Cytochrome P450 2C8	enzyme
DB00688	Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B1	transporter
DB00688	Mycophenolate mofetil	Solute carrier organic anion transporter family member 1B3	transporter
DB00688	Mycophenolate mofetil	ATP-binding cassette sub-family G member 2	transporter
DB00688	Mycophenolate mofetil	P-glycoprotein 1	transporter
DB00688	Mycophenolate mofetil	6-pyruvoyl tetrahydrobiopterin synthase	target
DB00688	Mycophenolate mofetil	Carboxylic ester hydrolase	enzyme
DB00688	Mycophenolate mofetil	Canalicular multispecific organic anion transporter 1	transporter
DB00860	Prednisolone	Corticosteroid-binding globulin	carrier
DB00860	Prednisolone	Cytochrome P450 3A4	enzyme
DB00860	Prednisolone	Glucocorticoid receptor	target
DB00860	Prednisolone	Solute carrier organic anion transporter family member 1A2	transporter
DB00860	Prednisolone	P-glycoprotein 1	transporter
DB00860	Prednisolone	Serum albumin	carrier
DB15566	Prednisolone acetate	Corticosteroid-binding globulin	carrier
DB15566	Prednisolone acetate	Cytochrome P450 3A4	enzyme
DB15566	Prednisolone acetate	Glucocorticoid receptor	target
DB15566	Prednisolone acetate	Solute carrier organic anion transporter family member 1A2	transporter
DB15566	Prednisolone acetate	P-glycoprotein 1	transporter
DB15566	Prednisolone acetate	Serum albumin	carrier
DB00877	Sirolimus	Cytochrome P450 3A4	enzyme
DB00877	Sirolimus	Serine/threonine-protein kinase mTOR	target
DB00877	Sirolimus	Cytochrome P450 3A5	enzyme
DB00877	Sirolimus	Cytochrome P450 3A7	enzyme
DB00877	Sirolimus	P-glycoprotein 1	transporter
DB00877	Sirolimus	Solute carrier organic anion transporter family member 1B1	transporter
DB00877	Sirolimus	Multidrug and toxin extrusion protein 1	transporter
DB00877	Sirolimus	Serum albumin	carrier
DB00877	Sirolimus	Alpha-1-acid glycoprotein 1	carrier
DB00877	Sirolimus	Apolipoproteins	carrier

Drug	Drug Name	Phase	Status	Count
DB00864	Tacrolimus	0	Completed	1
DB00877	Sirolimus	1	Completed	1
DB00316	Acetaminophen	2	Completed	1
DB00087	Alemtuzumab	2	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	2	Completed	3
DB06681	Belatacept	2	Completed	2
DB00188	Bortezomib	2	Completed	1
DB16741	Bortezomib D-mannitol	2	Completed	1
DB00091	Cyclosporine	2	Completed	1
DB01075	Diphenhydramine	2	Completed	1
DB08868	Fingolimod	2	Enrolling by Invitation	1
DB06404	Human C1-esterase inhibitor	2	Completed	1
DB06404	Human C1-esterase inhibitor	2	Withdrawn	1
DB00028	Human immunoglobulin G	2	Recruiting	1
DB11228	Methylcellulose	2	Enrolling by Invitation	1
DB00959	Methylprednisolone	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	2
DB01024	Mycophenolic acid	2	Recruiting	1
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Recruiting	1
DB00864	Tacrolimus	2	Completed	1
DB00864	Tacrolimus	2	Recruiting	1
DB00074	Basiliximab	3	Completed	1
DB00091	Cyclosporine	3	Completed	3
DB01590	Everolimus	3	Completed	3
DB00688	Mycophenolate mofetil	3	Completed	1
DB01024	Mycophenolic acid	3	Completed	1
DB00073	Rituximab	3	Unknown Status	1
DB09153	Sodium chloride	3	Unknown Status	1
DB09154	Sodium citrate	3	Unknown Status	1
DB00864	Tacrolimus	3	Completed	1
DB00087	Alemtuzumab	4	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	4	Unknown Status	1
DB00207	Azithromycin	4	Completed	1
DB06681	Belatacept	4	Completed	1
DB00201	Caffeine	4	Completed	1
DB00091	Cyclosporine	4	Completed	1
DB00091	Cyclosporine	4	Unknown Status	1
DB00514	Dextromethorphan	4	Completed	1
DB04465	Lactose	4	Completed	1
DB00678	Losartan	4	Completed	1
DB00959	Methylprednisolone	4	Completed	1
DB00683	Midazolam	4	Completed	1
DB00471	Montelukast	4	Completed	1
DB00688	Mycophenolate mofetil	4	Completed	1
DB00688	Mycophenolate mofetil	4	Unknown Status	1
DB01024	Mycophenolic acid	4	Unknown Status	1
DB00338	Omeprazole	4	Completed	1
DB00860	Prednisolone	4	Completed	1
DB00635	Prednisone	4	Unknown Status	1
DB00073	Rituximab	4	Completed	1
DB00877	Sirolimus	4	Completed	5
DB00877	Sirolimus	4	Unknown Status	1
DB00864	Tacrolimus	4	Completed	5
DB00864	Tacrolimus	4	Unknown Status	1
DB00087	Alemtuzumab	Not Available	Active Not Recruiting	1