Depression Acute

Also known as: Acute Depression / Acute depression (disorder) / Major depressive disorder, recurrent, unspecified / Depressive state / Depression NOS / Depressed state / Depression / Depression mental

Drug	Drug Name	Drug Description
DB00321	Amitriptyline	A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.

Drug	Drug Name	Target	Type
DB00321	Amitriptyline	Sodium-dependent serotonin transporter	target
DB00321	Amitriptyline	Sodium-dependent noradrenaline transporter	target
DB00321	Amitriptyline	Potassium voltage-gated channel subfamily KQT member 2	target
DB00321	Amitriptyline	Alpha-2A adrenergic receptor	target
DB00321	Amitriptyline	Cytochrome P450 1A2	enzyme
DB00321	Amitriptyline	Cytochrome P450 2C19	enzyme
DB00321	Amitriptyline	Cytochrome P450 2D6	enzyme
DB00321	Amitriptyline	Serum albumin	carrier
DB00321	Amitriptyline	Alpha-1-acid glycoprotein 1	carrier
DB00321	Amitriptyline	Histamine H1 receptor	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 2A	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 1A	target
DB00321	Amitriptyline	Alpha-1A adrenergic receptor	target
DB00321	Amitriptyline	Cytochrome P450 3A4	enzyme
DB00321	Amitriptyline	Cytochrome P450 3A5	enzyme
DB00321	Amitriptyline	Potassium voltage-gated channel subfamily A member 1	target
DB00321	Amitriptyline	Alpha-1D adrenergic receptor	target
DB00321	Amitriptyline	Delta-type opioid receptor	target
DB00321	Amitriptyline	Kappa-type opioid receptor	target
DB00321	Amitriptyline	High affinity nerve growth factor receptor	target
DB00321	Amitriptyline	BDNF/NT-3 growth factors receptor	target
DB00321	Amitriptyline	Cytochrome P450 2C9	enzyme
DB00321	Amitriptyline	Cytochrome P450 2B6	enzyme
DB00321	Amitriptyline	Cytochrome P450 2C8	enzyme
DB00321	Amitriptyline	Histamine H2 receptor	target
DB00321	Amitriptyline	Histamine H4 receptor	target
DB00321	Amitriptyline	Sigma non-opioid intracellular receptor 1	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 2C	target
DB00321	Amitriptyline	Alpha-1B adrenergic receptor	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 7	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 1D	target
DB00321	Amitriptyline	Mu-type opioid receptor	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 1B	target
DB00321	Amitriptyline	5-hydroxytryptamine receptor 6	target
DB00321	Amitriptyline	Potassium voltage-gated channel subfamily KQT member 3	target
DB00321	Amitriptyline	UDP-glucuronosyltransferase 2B10	enzyme
DB00321	Amitriptyline	5-hydroxytryptamine receptor 1C	target
DB00321	Amitriptyline	Muscarinic acetylcholine receptor	target
DB00321	Amitriptyline	HERG human cardiac K+ channel	target
DB00321	Amitriptyline	P-glycoprotein 1	transporter
DB00321	Amitriptyline	UDP-glucuronosyltransferase 1-4	enzyme
DB00321	Amitriptyline	Glutathione S-transferases (Cytosolic)	enzyme

Drug	Drug Name	Phase	Status	Count
DB01221	Ketamine	1	Terminated	1
DB01221	Ketamine	4	Completed	1
DB09153	Sodium chloride	4	Completed	1