Persistent Depressive Disorder (Dysthymia)

Also known as: Persistent Depressive Disorder, Dysthymia / Dysthymic Disorder / Dysthymia / Persistent Depressive Disorder / Dysthymia (disorder) / Persistent depressive disorder (disorder) / Depressive personality disorder / Depression, Neurotic / Neurotic depression / Depression neurotic / Depression, unspecified / Depressive illness / Depressive neurosis / Depressive disorder (disorder) / Depressive disorder / Depressive disorders

Drug	Drug Name	Drug Description
DB00934	Maprotiline	A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression.
DB00370	Mirtazapine	A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.

Drug	Drug Name	Target	Type
DB00934	Maprotiline	Histamine H1 receptor	target
DB00934	Maprotiline	Sodium-dependent noradrenaline transporter	target
DB00934	Maprotiline	Alpha-1 adrenergic receptors	target
DB00934	Maprotiline	Cytochrome P450 2D6	enzyme
DB00934	Maprotiline	Alpha-1-acid glycoprotein 1	carrier
DB00934	Maprotiline	Muscarinic acetylcholine receptor M1	target
DB00934	Maprotiline	Muscarinic acetylcholine receptor M2	target
DB00934	Maprotiline	Muscarinic acetylcholine receptor M3	target
DB00934	Maprotiline	Muscarinic acetylcholine receptor M4	target
DB00934	Maprotiline	Muscarinic acetylcholine receptor M5	target
DB00934	Maprotiline	Cytochrome P450 1A2	enzyme
DB00934	Maprotiline	5-hydroxytryptamine receptor 2A	target
DB00934	Maprotiline	5-hydroxytryptamine receptor 2C	target
DB00934	Maprotiline	5-hydroxytryptamine receptor 7	target
DB00934	Maprotiline	Dopamine D2 receptor	target
DB00934	Maprotiline	Alpha-2 adrenergic receptors	target
DB00370	Mirtazapine	5-hydroxytryptamine receptor 2A	target
DB00370	Mirtazapine	5HT3 serotonin receptor	target
DB00370	Mirtazapine	Alpha-2A adrenergic receptor	target
DB00370	Mirtazapine	5-hydroxytryptamine receptor 2C	target
DB00370	Mirtazapine	Kappa-type opioid receptor	target
DB00370	Mirtazapine	Histamine H1 receptor	target
DB00370	Mirtazapine	Cytochrome P450 1A2	enzyme
DB00370	Mirtazapine	Cytochrome P450 3A4	enzyme
DB00370	Mirtazapine	Cytochrome P450 2D6	enzyme
DB00370	Mirtazapine	Alpha-1 adrenergic receptors	target
DB00370	Mirtazapine	Sodium-dependent serotonin transporter	transporter

Drug	Drug Name	Phase	Status	Count
DB00472	Fluoxetine	1 / 2	Completed	1
DB00458	Imipramine	1 / 2	Completed	1
DB01156	Bupropion	2	Completed	1
DB00215	Citalopram	2	Completed	1
DB00988	Dopamine	2	Completed	1
DB01175	Escitalopram	2	Completed	2
DB14509	Lithium carbonate	2	Completed	1
DB00368	Norepinephrine	2	Completed	2
DB11133	Omega-3 fatty acids	2	Unknown Status	1
DB00413	Pramipexole	2	Completed	1
DB08839	Serotonin	2	Completed	2
DB01238	Aripiprazole	4	Withdrawn	1
DB06413	Armodafinil	4	Completed	1
DB01156	Bupropion	4	Completed	4
DB01156	Bupropion	4	Withdrawn	1
DB00190	Carbidopa	4	Terminated	1
DB00215	Citalopram	4	Completed	1
DB06700	Desvenlafaxine	4	Completed	1
DB00476	Duloxetine	4	Completed	3
DB01175	Escitalopram	4	Completed	6
DB00458	Imipramine	4	Completed	2
DB01235	Levodopa	4	Completed	1
DB01235	Levodopa	4	Terminated	1
DB01104	Sertraline	4	Completed	1
DB13944	Testosterone enanthate	4	Unknown Status	1
DB00285	Venlafaxine	4	Completed	1
DB06700	Desvenlafaxine	Not Available	Completed	1
DB00184	Nicotine	Not Available	Recruiting	1
DB01224	Quetiapine	Not Available	Completed	1