Locally Advanced Cholangiocarcinoma
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB14568 | Ivosidenib | An isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults with a susceptible IDH1 mutation. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB14568 | Ivosidenib | Isocitrate dehydrogenase [NADP] cytoplasmic | target |
| DB14568 | Ivosidenib | Cytochrome P450 3A4 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2B6 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2C9 | enzyme |
| DB14568 | Ivosidenib | Cytochrome P450 2C8 | enzyme |
| DB14568 | Ivosidenib | Solute carrier family 22 member 8 | transporter |
| DB14568 | Ivosidenib | P-glycoprotein 1 | transporter |