Processing-deficient Progeroid Laminopathies

Drug	Drug Name	Drug Description
DB06448	Lonafarnib	A potent farnesyl transferase inhibitor used to reduce mortality associated with Hutchinson-Gilford progeria syndrome (HGPS) and other progeroid laminopathies.

Drug	Drug Name	Target	Type
DB06448	Lonafarnib	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	target
DB06448	Lonafarnib	P-glycoprotein 1	transporter
DB06448	Lonafarnib	Protein farnesyltransferase subunit beta	target
DB06448	Lonafarnib	Cytochrome P450 3A Subfamily	enzyme
DB06448	Lonafarnib	Cytochrome P450 2C8	enzyme
DB06448	Lonafarnib	Cytochrome P450 2C19	enzyme
DB06448	Lonafarnib	Cytochrome P450 1A2	enzyme
DB06448	Lonafarnib	Cytochrome P450 2A6	enzyme
DB06448	Lonafarnib	Cytochrome P450 2C9	enzyme
DB06448	Lonafarnib	Cytochrome P450 2E1	enzyme
DB06448	Lonafarnib	Solute carrier organic anion transporter family member 1B1	transporter
DB06448	Lonafarnib	Solute carrier organic anion transporter family member 1B3	transporter
DB06448	Lonafarnib	ATP-binding cassette sub-family G member 2	transporter
DB06448	Lonafarnib	Cytochrome P450 3A4	enzyme
DB06448	Lonafarnib	Cytochrome P450 3A5	enzyme
DB06448	Lonafarnib	Canalicular multispecific organic anion transporter 1	transporter

Drug	Drug Name	Phase	Status	Count