High risk Primary Myelofibrosis (PMF)

Also known as: High-Risk Primary Myelofibrosis

Drug	Drug Name	Drug Description
DB11697	Pacritinib	A kinase inhibitor used for the treatment of primary and secondary myelofibrosis in adult patients with significantly reduced platelet counts.

Drug	Drug Name	Target	Type
DB11697	Pacritinib	Cytochrome P450 3A4	enzyme
DB11697	Pacritinib	Cytochrome P450 1A2	enzyme
DB11697	Pacritinib	Tyrosine-protein kinase JAK2	target
DB11697	Pacritinib	Receptor-type tyrosine-protein kinase FLT3	target
DB11697	Pacritinib	P-glycoprotein 1	transporter
DB11697	Pacritinib	ATP-binding cassette sub-family G member 2	transporter
DB11697	Pacritinib	Solute carrier family 22 member 1	transporter
DB11697	Pacritinib	Cytochrome P450 2C19	enzyme
DB11697	Pacritinib	Solute carrier family 22 member 2	transporter

Drug	Drug Name	Phase	Status	Count