Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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Displaying entries 1 - 25 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Cetuximab	Low affinity immunoglobulin gamma Fc region receptor II-a Gene symbol: FCGR2A UniProt: P12318	---	(C;T) / (T;T)	H allelle (rs1801274)	Effect Directly Studied	Patients with this genotype may have increased progression-free survival time when using cetuximab to treat colorectal cancer.	Details
Cetuximab	Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637	---	(G;T) / (T;T)	G > T (rs396991)	Effect Directly Studied	Patients with this genotype have increased progression-free survival time when using cetuximab to treat colorectal cancer.	Details
Infliximab	Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637	---	(C;C)	CC Allele (homozygous) (rs1801274)	Effect Directly Studied	Patients with this genotype have increased ACR20 response when using infliximab to treat rheumatoid arthritis.	Details
Trastuzumab	Receptor tyrosine-protein kinase erbB-2 Gene symbol: ERBB2 UniProt: P04626	---	(A;G)	G Allele, heterozygote (rs1136201)	ADR Directly Studied	Patients with this genotype have increased risk of cardiotoxicity with trastuzumab.	Details
Rituximab	Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637	FCGR3A	(G;G) / (G;T)	T > G (rs396991)	Effect Directly Studied	Patients with this genotype have increased frequency of anti-tumor response when using rituximab to treat diffuse large B-cell lymphoma, follicular lymphoma, or [follicular non-Hodgkin lymphoma].	Details
Pravastatin	Kinesin-like protein KIF6 Gene symbol: KIF6 UniProt: Q6ZMV9	---	(C;C) / (C;T)	C Allele (rs20455)	Effect Directly Studied	Patients with this genotype have a greater reduction in risk of a major cardiovascular event with high dose pravastatin.	Details
Pravastatin	3-hydroxy-3-methylglutaryl-coenzyme A reductase Gene symbol: HMGCR UniProt: P04035	---	(A;T)	T Allele (rs17244841)	Effect Directly Studied	Patients with this genotype have a lesser reduction in LDL cholesterol with pravastatin.	Details
Ramipril	Angiotensin-converting enzyme Gene symbol: ACE UniProt: P12821	---	(A;A) / (G;G)	A Allele, homozygote (rs4344) G Allele, homozygote (rs4344)	Effect Directly Studied	Patients with this genotype have a shorter time to lowering of blood pressure with ramipril	Details
Caffeine	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	---	(A;C) / (C;C)	C allele (rs762551)	ADR Directly Studied	Patients with this genotype have increased risk of a non-fatal myocardial infarction with caffeine	Details
Sildenafil	Angiotensin-converting enzyme Gene symbol: ACE UniProt: P12821	---	Not Available	Alu insertions (rs1799752) Alu insertions (rs4340) Alu insertions (rs13447447) show all 4 …	Effect Directly Studied	Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction	Details
Sildenafil	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Gene symbol: GNB3 UniProt: P16520	---	(T;T)	T allele, homozygote (rs5443)	Effect Directly Studied	Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction	Details
Citalopram	Glutamate receptor ionotropic, kainate 2 Gene symbol: GRIK2 UniProt: Q13002	---	(C;C)	C Allele, homozygote (rs2518224)	ADR Directly Studied	Patients with this genotype have increased frequency of suicidal ideation with citalopram	Details
Citalopram	Glutamate receptor 3 Gene symbol: GRIA3 UniProt: P42263	---	(G;A) / (G;G)	G allele (rs4825476)	ADR Directly Studied	Patients with this genotype have increased frequency of suicidal ideation with citalopram	Details
Citalopram	Multidrug resistance protein 1 Gene symbol: ABCB1 UniProt: P08183	---	(C;C) / (C;T)	C Allele (rs2032583)	Effect Directly Studied	Patients with this genotype have an increased likelihood of remission when using citalopram to treat major depressive disorder	Details
Citalopram	5-hydroxytryptamine receptor 2A Gene symbol: HTR2A UniProt: P28223	---	(A;A)	A Allele (rs7997012)	Effect Directly Studied	Patients with this genotype have an increased likelihood of responding to citalopram when treating major depressive disorder	Details
Citalopram	Glutamate receptor ionotropic, kainate 4 Gene symbol: GRIK4 UniProt: Q16099	---	(C;C)	C Allele (rs1954787)	Effect Directly Studied	Patients with this genotype have an increased likelihood of responding to citalopram when treating major depressive disorder	Details
Citalopram	Cyclic AMP-responsive element-binding protein 1 Gene symbol: CREB1 UniProt: P16220	---	(T;T)	T allele, homozygous (rs4675690)	ADR Directly Studied	Male patients with this genotype have an increased risk of (condition: suicide) with (drug: citalopram).	Details
Eletriptan	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Gene symbol: GNB3 UniProt: P16520	---	(C;T) / (T;T)	T Allele (rs5443)	Effect Directly Studied	Patients with this genotype have an increased likelihood of responding to elitriptan when treating (condition: cluster headache).	Details
Phenytoin	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*3	(A;C) / (C;C)	C Allele (rs1057910)	Effect Directly Studied	Patients with this genotype have reduced metabolism of phenytoin.	Details
Metoprolol	Beta-1 adrenergic receptor Gene symbol: ADRB1 UniProt: P08588	---	(A;A)	A Allele (rs1801252)	Effect Directly Studied	Patients with this genotype have a greater reduction in blood pressure with metoprolol.	Details
Metoprolol	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	(A;A)	A allele (rs3892097)	Directly Studied Effect	Patients with this genotype have reduced metabolism of metoprolol.	Details
Metoprolol	Beta-1 adrenergic receptor Gene symbol: ADRB1 UniProt: P08588	---	(C;C) / (C;G)	G > C (rs1801253)	Effect Directly Studied	Patients with this genotype have a greater reduction in blood pressure with metoprolol.	Details
Theophylline	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	-2964(G/A)	(A;A) / (G;A)	A Allele	Effect Directly Studied	Patients with this genotype have reduced metabolism of theophylline.	Details
Venlafaxine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	(A;A)	A Allele (rs3892097)	Effect Directly Studied	Patients with this genotype have reduced metabolism of venlafaxine.	Details
Venlafaxine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	(-;-) / (-;T)	T deletion (rs5030655) T deletion, homozygote (rs5030655)	Effect Directly Studied	Patients with this genotype have reduced metabolism of venlafaxine.	Details

Displaying entries 1 - 25 of 6330 in total

Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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