Cetuximab | Low affinity immunoglobulin gamma Fc region receptor II-a Gene symbol: FCGR2A UniProt: P12318 | --- | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype may have increased progression-free survival time when using cetuximab to treat colorectal cancer. | Details |
Cetuximab | Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637 | --- | (G;T) / (T;T) | | Effect Directly Studied | Patients with this genotype have increased progression-free survival time when using cetuximab to treat colorectal cancer. | Details |
Infliximab | Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637 | --- | (C;C) | | Effect Directly Studied | Patients with this genotype have increased ACR20 response when using infliximab to treat rheumatoid arthritis. | Details |
Trastuzumab | Receptor tyrosine-protein kinase erbB-2 Gene symbol: ERBB2 UniProt: P04626 | --- | (A;G) | | ADR Directly Studied | Patients with this genotype have increased risk of cardiotoxicity with trastuzumab. | Details |
Rituximab | Low affinity immunoglobulin gamma Fc region receptor III-A Gene symbol: FCGR3A UniProt: P08637 | FCGR3A | (G;G) / (G;T) | | Effect Directly Studied | Patients with this genotype have increased frequency of anti-tumor response when using rituximab to treat diffuse large B-cell lymphoma, follicular lymphoma, or [follicular non-Hodgkin lymphoma]. | Details |
Pravastatin | Kinesin-like protein KIF6 Gene symbol: KIF6 UniProt: Q6ZMV9 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have a greater reduction in risk of a major cardiovascular event with high dose pravastatin. | Details |
Pravastatin | 3-hydroxy-3-methylglutaryl-coenzyme A reductase Gene symbol: HMGCR UniProt: P04035 | --- | (A;T) | | Effect Directly Studied | Patients with this genotype have a lesser reduction in LDL cholesterol with pravastatin. | Details |
Ramipril | Angiotensin-converting enzyme Gene symbol: ACE UniProt: P12821 | --- | (A;A) / (G;G) | | Effect Directly Studied | Patients with this genotype have a shorter time to lowering of blood pressure with ramipril | Details |
Caffeine | Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177 | --- | (A;C) / (C;C) | | ADR Directly Studied | Patients with this genotype have increased risk of a non-fatal myocardial infarction with caffeine | Details |
Sildenafil | Angiotensin-converting enzyme Gene symbol: ACE UniProt: P12821 | --- | Not Available | show all 4 … | Effect Directly Studied | Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction | Details |
Sildenafil | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Gene symbol: GNB3 UniProt: P16520 | --- | (T;T) | | Effect Directly Studied | Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction | Details |
Citalopram | Glutamate receptor ionotropic, kainate 2 Gene symbol: GRIK2 UniProt: Q13002 | --- | (C;C) | | ADR Directly Studied | Patients with this genotype have increased frequency of suicidal ideation with citalopram | Details |
Citalopram | Glutamate receptor 3 Gene symbol: GRIA3 UniProt: P42263 | --- | (G;A) / (G;G) | | ADR Directly Studied | Patients with this genotype have increased frequency of suicidal ideation with citalopram | Details |
Citalopram | Multidrug resistance protein 1 Gene symbol: ABCB1 UniProt: P08183 | --- | (C;C) / (C;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of remission when using citalopram to treat major depressive disorder | Details |
Citalopram | 5-hydroxytryptamine receptor 2A Gene symbol: HTR2A UniProt: P28223 | --- | (A;A) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of responding to citalopram when treating major depressive disorder | Details |
Citalopram | Glutamate receptor ionotropic, kainate 4 Gene symbol: GRIK4 UniProt: Q16099 | --- | (C;C) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of responding to citalopram when treating major depressive disorder | Details |
Citalopram | Cyclic AMP-responsive element-binding protein 1 Gene symbol: CREB1 UniProt: P16220 | --- | (T;T) | | ADR Directly Studied | Male patients with this genotype have an increased risk of (condition: suicide) with (drug: citalopram). | Details |
Eletriptan | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Gene symbol: GNB3 UniProt: P16520 | --- | (C;T) / (T;T) | | Effect Directly Studied | Patients with this genotype have an increased likelihood of responding to elitriptan when treating (condition: cluster headache). | Details |
Phenytoin | Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712 | CYP2C9*3 | (A;C) / (C;C) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of phenytoin. | Details |
Metoprolol | Beta-1 adrenergic receptor Gene symbol: ADRB1 UniProt: P08588 | --- | (A;A) | | Effect Directly Studied | Patients with this genotype have a greater reduction in blood pressure with metoprolol. | Details |
Metoprolol | Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635 | CYP2D6*4 | (A;A) | | Directly Studied Effect | Patients with this genotype have reduced metabolism of metoprolol. | Details |
Metoprolol | Beta-1 adrenergic receptor Gene symbol: ADRB1 UniProt: P08588 | --- | (C;C) / (C;G) | | Effect Directly Studied | Patients with this genotype have a greater reduction in blood pressure with metoprolol. | Details |
Theophylline | Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177 | -2964(G/A) | (A;A) / (G;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of theophylline. | Details |
Venlafaxine | Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635 | CYP2D6*4 | (A;A) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of venlafaxine. | Details |
Venlafaxine | Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635 | CYP2D6*6 | (-;-) / (-;T) | | Effect Directly Studied | Patients with this genotype have reduced metabolism of venlafaxine. | Details |