Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE000002)

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Identifier
DBSNPE000002, DBSNPE005523
Drug
Acetylsalicylic acid (DB00945)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
C Allelers1057910
Allele Name
CYP2C9*3
Genotype(s)
(A;C) / (C;C)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
Patients with this genotype have reduced metabolism of acetylsalicylic acid.
References
  1. Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [PubMed:12893985]