Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE000002)

Identifier

DBSNPE000002, DBSNPE005523

Drug

Acetylsalicylic acid (DB00945)

Interacting Gene/Enzyme

Cytochrome P450 2C9

Gene Name

CYP2C9

UniProt ID

P11712

Defining Change(s)

C Allele

Allele Name

CYP2C9*3

Genotype(s)

(A;C) / (C;C)

Type(s)

Effect Directly Studied

Groups

Non-functional CYP2C9; Decreased CYP2C9

Description

Patients with this genotype have reduced metabolism of acetylsalicylic acid.

References

Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [Article]