Pharmacogenomic Effect/ADR for Celecoxib (DBSNPE000003)

Identifier
DBSNPE000003, DBSNPE005542
Drug
Celecoxib (DB00482)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
C Allelers1057910
Allele Name
CYP2C9*3
Genotype(s)
(C;C) / (A;C)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
Patients with this genotype have reduced metabolism of celecoxib.
References
  1. Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [Article]