Pharmacogenomic Effect/ADR for Codeine (DBSNPE000008)
- Identifier
- DBSNPE000008, DBSNPE005619
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
T deletion, homozygote rs5030655 - Allele Name
- CYP2D6*6
- Genotype(s)
- (-;-)
- Type(s)
- Effect Directly Studied
- Groups
- Non-functional CYP2D6
- Description
- Patients with this genotype have reduced metabolism of codeine.
- References
- Desmeules J, Gascon MP, Dayer P, Magistris M: Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol. 1991;41(1):23-6. [PubMed:1782973]