Pharmacogenomic Effect/ADR for Dextromethorphan (DBSNPE000011)

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Identifier
DBSNPE000011, DBSNPE005679
Drug
Dextromethorphan (DB00514)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
A Allele, homozygoters3892097
Allele Name
CYP2D6*4
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of dextromethorphan.
References
  1. Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [Article]