Pharmacogenomic Effect/ADR for Dextromethorphan (DBSNPE000012)

Identifier
DBSNPE000012, DBSNPE005681
Drug
Dextromethorphan (DB00514)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
T deletion, homozygoters5030655
Allele Name
CYP2D6*6
Genotype(s)
(-;-)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of dextromethorphan.
References
  1. Bradford LD, Gaedigk A, Leeder JS: High frequency of CYP2D6 poor and "intermediate" metabolizers in black populations: a review and preliminary data. Psychopharmacol Bull. 1998;34(4):797-804. [Article]