Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE000019)

Identifier
DBSNPE000019, DBSNPE005781
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
A Allele, homozygoters4986893
Allele Name
CYP2C19*3
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C19
Description
Patients with this genotype have reduced metabolism of mephenytoin.
References
  1. De Morais SM, Wilkinson GR, Blaisdell J, Meyer UA, Nakamura K, Goldstein JA: Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994 Oct;46(4):594-8. [Article]