Pharmacogenomic Effect/ADR for Nortriptyline (DBSNPE000020)

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Identifier
DBSNPE000020, DBSNPE005790
Drug
Nortriptyline (DB00540)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
A Allelers3892097
Allele Name
CYP2D6*4
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of nortriptyline.
References
  1. Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH: Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Br J Clin Pharmacol. 2008 Apr;65(4):558-64. Epub 2007 Dec 7. [Article]