Pharmacogenomic Effect/ADR for Phenytoin (DBSNPE000023)

Identifier

DBSNPE000023, DBSNPE005835

Drug

Phenytoin (DB00252)

Interacting Gene/Enzyme

Cytochrome P450 2C9

Gene Name

CYP2C9

UniProt ID

P11712

Defining Change(s)

C Allele

Allele Name

CYP2C9*3

Genotype(s)

(A;C) / (C;C)

Type(s)

Effect Directly Studied

Groups

Non-functional CYP2C9; Decreased CYP2C9

Description

Patients with this genotype have reduced metabolism of phenytoin.

References

Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. [Article]