- Identifier
- DBSNPE000023, DBSNPE005835
- Drug
- Phenytoin (DB00252)
- Interacting Gene/Enzyme
- Cytochrome P450 2C9
- Gene Name
- CYP2C9
- UniProt ID
- P11712
- Defining Change(s)
- Allele Name
- CYP2C9*3
- Genotype(s)
- (A;C) / (C;C)
- Type(s)
- Effect Directly Studied
- Groups
- Non-functional CYP2C9; Decreased CYP2C9
- Description
- Patients with this genotype have reduced metabolism of phenytoin.
- References
- Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. [PubMed:15805193]