Pharmacogenomic Effect/ADR for Ramipril (DBSNPE000026)

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Identifier
DBSNPE000026, DBSNPE000027
Drug
Ramipril (DB00178)
Interacting Gene/Enzyme
Angiotensin-converting enzyme
Gene Name
ACE
UniProt ID
P12821
Defining Change(s)
A Allele, homozygoters4344
G Allele, homozygoters4344
Allele Name
Not Available
Genotype(s)
(A;A) / (G;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have a shorter time to lowering of blood pressure with ramipril
References
  1. Bhatnagar V, O'Connor DT, Schork NJ, Salem RM, Nievergelt CM, Rana BK, Smith DW, Bakris GL, Middleton JP, Norris KC, Wright JT, Cheek D, Hiremath L, Contreras G, Appel LJ, Lipkowitz MS: Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial. J Hypertens. 2007 Oct;25(10):2082-92. [Article]