Pharmacogenomic Effect/ADR for Cisplatin (DBSNPE000045)

Identifier
DBSNPE000045
Drug
Cisplatin (DB00515)
Interacting Gene/Enzyme
Glutathione S-transferase Mu 1
Gene Name
GSTM1
UniProt ID
P09488
Defining Change(s)
presence of functional GSTM1Not Available
Allele Name
GSTM1
Genotype(s)
Not Available
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin].
References
  1. Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [Article]