Pharmacogenomic Effect/ADR for Citalopram (DBSNPE000046)

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Identifier
DBSNPE000046
Drug
Citalopram (DB00215)
Interacting Gene/Enzyme
Glutamate receptor ionotropic, kainate 2
Gene Name
GRIK2
UniProt ID
Q13002
Defining Change(s)
C Allele, homozygoters2518224
Allele Name
Not Available
Genotype(s)
(C;C)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased frequency of suicidal ideation with citalopram
References
  1. Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ: Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. [PubMed:17898344]