Pharmacogenomic Effect/ADR for Methotrexate (DBSNPE000058)

Identifier
DBSNPE000058
Drug
Methotrexate (DB00563)
Interacting Gene/Enzyme
Canalicular multispecific organic anion transporter 1
Gene Name
ABCC2
UniProt ID
Q92887
Defining Change(s)
T alleleNot Available
Allele Name
ABCC2 IVS 23+56
Genotype(s)
(C;C) / (C;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of toxicity with methotrexate.
References
  1. Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton TJ, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL: Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. J Rheumatol. 2008 Apr;35(4):572-9. Epub 2008 Mar 15. [Article]