Pharmacogenomic Effect/ADR for Trastuzumab (DBSNPE000060)

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Identifier
DBSNPE000060
Drug
Trastuzumab (DB00072)
Interacting Gene/Enzyme
Receptor tyrosine-protein kinase erbB-2
Gene Name
ERBB2
UniProt ID
P04626
Defining Change(s)
G Allele, heterozygoters1136201
Allele Name
Not Available
Genotype(s)
(A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of cardiotoxicity with trastuzumab.
References
  1. Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [PubMed:17693647]