- Identifier
- DBSNPE000060
- Drug
- Trastuzumab (DB00072)
- Interacting Gene/Enzyme
- Receptor tyrosine-protein kinase erbB-2
- Gene Name
- ERBB2
- UniProt ID
- P04626
- Defining Change(s)
- Allele Name
- Not Available
- Genotype(s)
- (A;G)
- Type(s)
- ADR Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have increased risk of cardiotoxicity with trastuzumab.
- References
- Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [Article]