Pharmacogenomic Effect/ADR for Carvedilol (DBSNPE000070)

Identifier
DBSNPE000070, DBSNPE000071
Drug
Carvedilol (DB01136)
Interacting Gene/Enzyme
Beta-1 adrenergic receptor
Gene Name
ADRB1
UniProt ID
P08588
Defining Change(s)
C Allele, homozygousrs1801253
Allele Name
Not Available
Genotype(s)
(A;A) / (C;C) / (C;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype in ADRB1 have an increased likelihood of responding to carvedilol for the treatment of increased blood pressure.
References
  1. Johnson JA, Zineh I, Puckett BJ, McGorray SP, Yarandi HN, Pauly DF: Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003 Jul;74(1):44-52. [Article]