Pharmacogenomic Effect/ADR for Citalopram (DBSNPE000073)

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Identifier
DBSNPE000073
Drug
Citalopram (DB00215)
Interacting Gene/Enzyme
5-hydroxytryptamine receptor 2A
Gene Name
HTR2A
UniProt ID
P28223
Defining Change(s)
A Allelers7997012
Allele Name
Not Available
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased likelihood of responding to citalopram when treating major depressive disorder
References
  1. McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H: Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006 May;78(5):804-14. Epub 2006 Mar 20. [Article]