Pharmacogenomic Effect/ADR for Paroxetine (DBSNPE000081)

Identifier
DBSNPE000081
Drug
Paroxetine (DB00715)
Interacting Gene/Enzyme
Multidrug resistance protein 1
Gene Name
ABCB1
UniProt ID
P08183
Defining Change(s)
C Allelers2032583
Allele Name
Not Available
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have an increased likelihood of remission when using paroxetine to treat major depressive disorder.
References
  1. Kato M, Fukuda T, Serretti A, Wakeno M, Okugawa G, Ikenaga Y, Hosoi Y, Takekita Y, Mandelli L, Azuma J, Kinoshita T: ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):398-404. Epub 2007 Sep 15. [Article]