Pharmacogenomic Effect/ADR for Pravastatin (DBSNPE000082)
- Identifier
- DBSNPE000082
- Drug
- Pravastatin (DB00175)
- Interacting Gene/Enzyme
- Kinesin-like protein KIF6
- Gene Name
- KIF6
- UniProt ID
- Q6ZMV9
- Defining Change(s)
C Allele rs20455 - Allele Name
- Not Available
- Genotype(s)
- (C;C) / (C;T)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have a greater reduction in risk of a major cardiovascular event with high dose pravastatin.
- References
- Iakoubova OA, Tong CH, Rowland CM, Kirchgessner TG, Young BA, Arellano AR, Shiffman D, Sabatine MS, Campos H, Packard CJ, Pfeffer MA, White TJ, Braunwald E, Shepherd J, Devlin JJ, Sacks FM: Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol. 2008 Jan 29;51(4):435-43. doi: 10.1016/j.jacc.2007.05.057. [Article]