Pharmacogenomic Effect/ADR for Sildenafil (DBSNPE000087)

DocumentationBrowse all
Identifier
DBSNPE000087
Drug
Sildenafil (DB00203)
Interacting Gene/Enzyme
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Gene Name
GNB3
UniProt ID
P16520
Defining Change(s)
T allele, homozygoters5443
Allele Name
Not Available
Genotype(s)
(T;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased frequency of positive erectile response when using sildenafil to treat erectile dysfunction
References
  1. Sperling H, Eisenhardt A, Virchow S, Hauck E, Lenk S, Porst H, Stief C, Wetterauer U, Rubben H, Muller N, Siffert W: Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: a pilot study. J Urol. 2003 Mar;169(3):1048-51. [Article]