Pharmacogenomic Effect/ADR for Fluorouracil (DBSNPE000095)

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Identifier
DBSNPE000095, DBSNPE000096
Drug
Fluorouracil (DB00544)
Interacting Gene/Enzyme
Dihydropyrimidine dehydrogenase [NADP(+)]
Gene Name
DPYD
UniProt ID
Q12882
Defining Change(s)
C allelers1801265
G allelers1801159
Allele Name
Not Available
Genotype(s)
(A;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced metabolism of fluorouracil and increased risk of toxicity.
References
  1. Zhang H, Li YM, Zhang H, Jin X: DPYD*5 gene mutation contributes to the reduced DPYD enzyme activity and chemotherapeutic toxicity of 5-FU: results from genotyping study on 75 gastric carcinoma and colon carcinoma patients. Med Oncol. 2007;24(2):251-8. [Article]