Pharmacogenomic Effect/ADR for Fluorouracil (DBSNPE000097)

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Identifier
DBSNPE000097
Drug
Fluorouracil (DB00544)
Interacting Gene/Enzyme
Glutathione S-transferase P
Gene Name
GSTP1
UniProt ID
P09211
Defining Change(s)
A allelers1695
Allele Name
Not Available
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of toxicity with fluorouracil
References
  1. Agostini M, Pasetto LM, Pucciarelli S, Terrazzino S, Ambrosi A, Bedin C, Galdi F, Friso ML, Mescoli C, Urso E, Leon A, Lise M, Nitti D: Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy. Drugs Aging. 2008;25(6):531-9. [Article]