Pharmacogenomic Effect/ADR for Caffeine (DBSNPE000100)

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Identifier
DBSNPE000100
Drug
Caffeine (DB00201)
Interacting Gene/Enzyme
Cytochrome P450 1A2
Gene Name
CYP1A2
UniProt ID
P05177
Defining Change(s)
C allelers762551
Allele Name
Not Available
Genotype(s)
(A;C) / (C;C)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of a non-fatal myocardial infarction with caffeine
References
  1. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, CYP1A2 genotype, and risk of myocardial infarction. JAMA. 2006 Mar 8;295(10):1135-41. [Article]