Pharmacogenomic Effect/ADR for Carbamazepine (DBSNPE000102)

Identifier
DBSNPE000102, DBSNPE000103
Drug
Carbamazepine (DB00564)
Interacting Gene/Enzyme
Heat shock 70 kDa protein 1A/1B
Gene Name
HSPA1A
UniProt ID
P08107
Defining Change(s)
C allelers506770
C allelers1043620
Allele Name
Not Available
Genotype(s)
(C;C) / (C;G) / (C;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.
References
  1. Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Barratt BJ, Chadwick DW, Kevin Park B, Pirmohamed M: Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. [Article]