Pharmacogenomic Effect/ADR for Carbamazepine (DBSNPE000105)

Identifier
DBSNPE000105
Drug
Carbamazepine (DB00564)
Interacting Gene/Enzyme
HLA class I histocompatibility antigen, A-31 alpha chain
Gene Name
HLA-A
UniProt ID
P16189
Defining Change(s)
G allelers1264511
Allele Name
Not Available
Genotype(s)
(C;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of cutaneous hypersensitivity reactions with carbamazepine.
References
  1. Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT: Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics. 2006 Apr;16(4):297-306. [Article]