Pharmacogenomic Effect/ADR for Cisplatin (DBSNPE000107)

Identifier
DBSNPE000107, DBSNPE000108
Drug
Cisplatin (DB00515)
Interacting Gene/Enzyme
Low-density lipoprotein receptor-related protein 2
Gene Name
LRP2
UniProt ID
P98164
Defining Change(s)
Allele Name
Not Available
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin].
References
  1. Riedemann L, Lanvers C, Deuster D, Peters U, Boos J, Jurgens H, am Zehnhoff-Dinnesen A: Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Pharmacogenomics J. 2008 Feb;8(1):23-8. Epub 2007 Apr 24. [Article]