Pharmacogenomic Effect/ADR for Cisplatin (DBSNPE000109)

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Identifier
DBSNPE000109
Drug
Cisplatin (DB00515)
Interacting Gene/Enzyme
Glutathione S-transferase P
Gene Name
GSTP1
UniProt ID
P09211
Defining Change(s)
Allele Name
Not Available
Genotype(s)
(A;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin].
References
  1. Oldenburg J, Kraggerud SM, Brydoy M, Cvancarova M, Lothe RA, Fossa SD: Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study. J Transl Med. 2007 Dec 27;5:70. [Article]