Pharmacogenomic Effect/ADR for Citalopram (DBSNPE000110)
- Identifier
- DBSNPE000110, DBSNPE000111
- Drug
- Citalopram (DB00215)
- Interacting Gene/Enzyme
- Cyclic AMP-responsive element-binding protein 1
- Gene Name
- CREB1
- UniProt ID
- P16220
- Defining Change(s)
T allele, homozygous rs4675690 - Allele Name
- Not Available
- Genotype(s)
- (T;T)
- Type(s)
- ADR Directly Studied
- Groups
- Not Available
- Description
- Male patients with this genotype have an increased risk of (condition: suicide) with (drug: citalopram).
- References
- Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. [Article]