Pharmacogenomic Effect/ADR for Citalopram (DBSNPE000110)

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Identifier
DBSNPE000110, DBSNPE000111
Drug
Citalopram (DB00215)
Interacting Gene/Enzyme
Cyclic AMP-responsive element-binding protein 1
Gene Name
CREB1
UniProt ID
P16220
Defining Change(s)
T allele, homozygousrs4675690
Allele Name
Not Available
Genotype(s)
(T;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Male patients with this genotype have an increased risk of (condition: suicide) with (drug: citalopram).
References
  1. Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW: Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. [Article]