Pharmacogenomic Effect/ADR for Daunorubicin (DBSNPE000113)

Identifier
DBSNPE000113
Drug
Daunorubicin (DB00694)
Interacting Gene/Enzyme
Cytochrome P450 1B1
Gene Name
CYP1B1
UniProt ID
Q16678
Defining Change(s)
G allelers10932125
Allele Name
Not Available
Genotype(s)
(C;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in CYP1B1 may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy.
References
  1. Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [Article]