Pharmacogenomic Effect/ADR for Daunorubicin (DBSNPE000115)

Identifier
DBSNPE000115
Drug
Daunorubicin (DB00694)
Interacting Gene/Enzyme
SEC14-like protein 3
Gene Name
SEC14L3
UniProt ID
Q9UDX4
Defining Change(s)
T allelers6603859
Allele Name
Not Available
Genotype(s)
(G;T) / (T;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in SEC14L3 may be associated with an increased risk of drug-induced cytotoxicity from daunorubicin therapy.
References
  1. Huang RS, Duan S, Kistner EO, Bleibel WK, Delaney SM, Fackenthal DL, Das S, Dolan ME: Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381. [Article]