Pharmacogenomic Effect/ADR for Gemcitabine (DBSNPE000118)

Identifier
DBSNPE000118, DBSNPE000119
Drug
Gemcitabine (DB00441)
Interacting Gene/Enzyme
Ribonucleoside-diphosphate reductase large subunit
Gene Name
RRM1
UniProt ID
P23921
Defining Change(s)
A allele, homozygousrs9937
A allele, homozygousrs1042858
Allele Name
Not Available
Genotype(s)
(A;A)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of neutropenia and neurotoxicity with gemcitabine.
References
  1. Rha SY, Jeung HC, Choi YH, Yang WI, Yoo JH, Kim BS, Roh JK, Chung HC: An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Oncologist. 2007 Jun;12(6):622-30. [Article]