Pharmacogenomic Effect/ADR for Methotrexate (DBSNPE000124)

Identifier
DBSNPE000124
Drug
Methotrexate (DB00563)
Interacting Gene/Enzyme
Methylenetetrahydrofolate reductase
Gene Name
MTHFR
UniProt ID
P42898
Defining Change(s)
T allelers1801133
Allele Name
Not Available
Genotype(s)
(C;T) / (T;T)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of toxicity with methotrexate.
References
  1. Gemmati D, Ongaro A, Tognazzo S, Catozzi L, Federici F, Mauro E, Della Porta M, Campioni D, Bardi A, Gilli G, Pellati A, Caruso A, Scapoli GL, De Mattei M: Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival. Haematologica. 2007 Apr;92(4):478-85. [Article]
  2. Ongaro A, De Mattei M, Della Porta MG, Rigolin G, Ambrosio C, Di Raimondo F, Pellati A, Masieri FF, Caruso A, Catozzi L, Gemmati D: Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival. Haematologica. 2009 Oct;94(10):1391-8. doi: 10.3324/haematol.2009.008326. Epub 2009 Jul 31. [Article]